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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Androgen use may increase the risk of stroke, but more research is needed.

Women with severe frontal fibrosing alopecia are more likely to have rosacea.

Kelulut Honey can help regulate sex hormone receptors in rats with Polycystic Ovary Syndrome, similar to common medications.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

The document concludes that respectful, gender-affirming healthcare improves mental health and encourages continued medical care for transgender and non-binary individuals.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

The patient's high testosterone was reduced by a medication that suppresses gonadotropin.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

Menopause worsens skin, hair, and nails, affecting self-esteem and quality of life.

Centratherum anthelminticum seed extract effectively treats Polycystic Ovary Syndrome in rats.

Women with Polycystic Ovary Syndrome (PCOS) have a higher risk of developing type 2 diabetes due to insulin resistance.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Testosterone is crucial for development, growth, and various body functions in mammals.

The conclusion is that thorough investigation of hypertension and hormonal dysfunctions is important, and there may be a link between these conditions and cancer.

A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

Treating hair loss in both men and women is effective and improves quality of life.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

Research from 2011 to 2020 shows androgen receptors could be key for prognosis and treatment in certain breast cancers.

Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

The 2023 guideline advises a detailed approach for PCOS, focusing on early detection, lifestyle and medical treatments, and managing health risks.

Polycystic ovary syndrome, a disorder causing menstrual issues and infertility, can be treated with lifestyle changes, medication, herbal remedies, surgery, and assisted reproductive techniques like artificial insemination and IVF.

Understanding Polycystic Ovary Syndrome (PCOS) and its causes can lead to effective treatments.