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    Glossary Potassium Channels

    specialized proteins that regulate potassium ion flow in cells

    Potassium channels are specialized proteins found in the cell membrane that allow potassium ions (K+) to pass in and out of the cell. They play a crucial role in maintaining the cell's electrical balance and are essential for various physiological processes, including nerve signal transmission, muscle contraction, and heart function. These channels are highly selective, ensuring that only potassium ions can pass through, which helps regulate the cell's internal environment.

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    1. Blocking Potassium Channels (Kv1.3): A New Treatment Option for Alopecia Areata? Journal of Investigative Dermatology · 2013 · 28 citations
    2. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies Autoimmunity reviews · 2016 · 82 citations
    3. Sex differences in and hormonal regulation of Kv1 potassium channel gene expression in the electric organ: Molecular control of a social signal Developmental neurobiology · 2007 · 22 citations
    4. Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease International Journal of Molecular Sciences · 2020 · 9 citations
    5. Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles Journal of Neurophysiology · 2025
    6. Hormonal Control of Cardiac Action Potential Phase 1 Currents in the Brugada Syndrome Revista Argentina de Cardiología · 2014
    7. iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata Journal of autoimmunity · 2018 · 27 citations
    8. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options Clinical and Experimental Medicine · 2021 · 56 citations
    9. Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata Frontiers in Cellular and Infection Microbiology · 2020 · 22 citations
    10. Frontiers in alopecia areata pathobiology research 2019 · 55 citations
    11. Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications Toxins · 2022 · 5 citations
    12. A “hair‐raising” history of alopecia areata Experimental Dermatology · 2020 · 15 citations
    13. Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives International Journal of Molecular Sciences · 2026
    14. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    15. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management 2017 · 102 citations
    16. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    17. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    18. Immunopathogenesis and Experimental Models of Alopecia Areata: From Mechanistic Insights to Translational Platforms Clinical Reviews in Allergy & Immunology · 2026
    19. Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo Journal of Investigative Dermatology · 2026
    20. Immune therapies for alopecia areata: evidence and new perspectives Expert Review of Clinical Immunology · 2025 · 5 citations
    21. Potassium channel openers: pharmacological and clinical aspects Fundamental & Clinical Pharmacology · 1992 · 119 citations
    22. Potassium Channel Conductance: A Mechanism Affecting Hair Growth both In Vitro and In Vivo Journal of Investigative Dermatology · 1992 · 82 citations
    23. Potassium channel conductance as a control mechanism in hair follicles Journal of Investigative Dermatology · 1993 · 42 citations
    24. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005 · 35 citations
    25. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993 · 31 citations
    26. Potassium Channel Conductance as a Control Mechanism in Hair Follicles. Journal of Investigative Dermatology · 1993 · 30 citations
    27. Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat Hypertension · 2013 · 28 citations
    28. Potassium channel openers: therapeutic potential in cardiology and medicine Expert Opinion on Pharmacotherapy · 2001 · 25 citations
    29. KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors Journal of Biological Chemistry · 2016 · 19 citations
    30. Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells Journal of Dermatological Science · 1994 · 16 citations