98 citations
,
July 2014 in “Trends in Molecular Medicine” This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.
85 citations
,
May 2019 in “Journal of neuroendocrinology” This review examines the neuroendocrine mechanisms underlying seasonal changes in mammals and highlights areas needing further research, reporting no new experimental results.
60 citations
,
August 2005 in “Endocrinology” This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.
56 citations
,
November 2010 in “Pigment Cell & Melanoma Research” This article discusses the role of neurohormones and neuropeptides in hair follicle pigmentation and outlines promising neuroendocrinological strategies to address greying and damage, but reports no new clinical results.
53 citations
,
January 2017 in “Skin appendage disorders” This review discusses botulinum toxin's experimental off-label uses in dermatology, highlighting promising results but emphasizing the need for more clinical trials to confirm efficacy and safety.
43 citations
,
October 2005 in “Molecular and cellular endocrinology” This review discusses how the CRH/POMC systems may regulate human hair follicle pigmentation and highlights the concept of "self-similarity" in melanocortin systems at both local and systemic levels, without presenting new experimental results.
32 citations
,
October 2004 in “Experimental Dermatology” This study found that α-MSH acts as a modulator of inflammatory and fibrogenic responses in human fibroblastic skin cells, indicating potential therapeutic options for fibrotic skin disorders and inflammatory diseases of the hair follicle.
27 citations
,
April 2017 in “British Journal of Dermatology” This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.
21 citations
,
February 2023 in “Pharmaceuticals” This study reports that extracts from pomegranate leaves contain bioactive compounds with antioxidant, antimicrobial, and skin-beneficial properties, suggesting their potential use in nutraceutical and cosmeceutical applications.
20 citations
,
July 2013 in “International Journal of Dermatology” This review addresses obesity-related dermatoses and highlights the potential increased risk of skin cancer associated with obesity; it presents no new clinical findings.
17 citations
,
September 2024 in “Cosmetics” This study assessed the antioxidant properties and contents of carotenoids and chlorophylls in 10 plant oils, finding fenugreek seed oil to be highest in carotenoids and pomegranate oil most active against free radicals, highlighting their potential as natural materials with antioxidant benefits.
13 citations
,
July 1973 in “Archives of dermatology” This letter to the editor raises concerns about the possibility of cornrowing leading to dermatologic problems such as traction alopecia, paralleling issues seen with other cosmetic fads.
10 citations
,
June 2021 in “Journal of Investigative Dermatology” GNPTAB gene is crucial for normal hair color in humans and mice.
9 citations
,
June 2020 in “BMC Molecular and Cell Biology” This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.
9 citations
,
January 2005 in “Experimental Dermatology” This study found that human hair follicles can function like a peripheral hypothalamic-pituitary-adrenal axis, synthesizing cortisol in response to corticotropin-releasing hormone and adrenocorticotropic hormone stimulation.
7 citations
,
April 2019 in “Animal biotechnology” This study observed that POMP is strongly expressed in the root sheath hair follicles of Liaoning Cashmere goats and its expression can be regulated by certain factors, which may influence cashmere growth.
6 citations
,
October 2018 in “PLoS ONE” This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.
5 citations
,
January 2024 in “Advances in Pharmacological and Pharmaceutical Sciences” This review explored the biological properties of Punica granatum, noting its antioxidant, anti-inflammatory, and antimicrobial activities, and highlighted its potential as a therapeutic agent for various conditions; however, more extensive clinical trials are needed to confirm its effectiveness and safety.
5 citations
,
May 2022 in “Molecules” This article reviews the literature on the off-label use of botulinum toxin for dermatological conditions, highlighting its potential effectiveness in treating rosacea, anal fissures, Raynaud phenomenon, hypertrophic scars, keloids, and hidradenitis suppurativa.
4 citations
,
July 2022 in “The Journal of Clinical Endocrinology & Metabolism” This study identified a novel homozygous mutation in the 5'-UTR of the POMC gene, suggesting a new molecular mechanism for the syndrome of adrenal insufficiency, obesity, and red hair.
2 citations
,
August 2023 in “The Journal of Animal and Plant Sciences” This study identified 1277 genomic regions selected for traits in indigenous Chinese goats, including cashmere fiber, reproduction, size, and high-altitude adaptation, revealing key candidate genes for these phenotypes through whole-genome resequencing.
2 citations
,
April 2020 in “International journal of research in pharmaceutical sciences” This review discusses the use of ten common Malaysian medicinal plants in cosmetic formulations for treating skin and hair conditions and reports no new clinical results.
2 citations
,
August 2013 in “The Lancet. Diabetes & endocrinology” This report discusses the FDA's third denial of approval for Aveed, a long-acting testosterone injection by Endo Pharmaceuticals, citing continued safety concerns including severe side effects.
2 citations
,
October 1999 in “Annals of the New York Academy of Sciences” This article discusses plasma β-endorphin concentrations during natural and artificially induced winter hair growth in mink but reports no new clinical findings.
1 citations
,
December 2022 in “Research journal of topical and cosmetic sciences” This study evaluated a polyherbal shampoo containing natural ingredients and found it demonstrated good froth stability, cleansing ability, and conditioning activity, but called for further validation of its overall quality.
1 citations
,
December 2014 in “Journal of the Society of Cosmetic Scientists of Korea” This study found that corticotropin-releasing factor influences cytokine expression related to hair growth in human dermal papilla cells and suggests CRF receptor antagonists could be potential treatments for stress-induced hair loss.
1 citations
,
January 2013 in “Springer eBooks” Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.
1 citations
,
January 2013 in “Journal of S C C J” This study suggests that scalp massage may reduce stress, as indicated by decreased salivary cortisol and increased secretory immunoglobulin A, and improve comfort by reducing physical fatigue and negative emotions.
January 2022 in “Social Science Research Network” In this study, researchers developed a long-lasting antibacterial coating for medical implants by anchoring silver nanoparticles onto polyamide surfaces, demonstrating potential to improve implant safety and effectiveness by reducing infection and inflammation.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.