Off-Label Use of Botulinum Toxin in Dermatology: Current State of the Art
May 2022
in “
Molecules
”
botulinum toxin BoNT BoNT-A BoNT-B androgenetic alopecia AGA hair count hidradenitis suppurativa rosacea erythema plaque psoriasis inverse psoriasis Hailey-Hailey disease eccrine nevus oily skin pompholyx Darier’s disease hypertrophic scars primary hyperhidrosis pharyngitis flu-like syndrome Botox androgenic alopecia hair growth hidradenitis psoriasis Hailey-Hailey sweaty skin eczema Darier’s scars hyperhidrosis sore throat flu symptoms
TLDR Botulinum toxin is effective for various skin conditions, but more research and awareness of side effects are needed.
The document reviews the off-label use of Botulinum toxin (BoNT) in dermatology, discussing its effectiveness in treating various skin conditions. A study involving 20 patients with hidradenitis suppurativa showed significant improvement after BoNT-B injections. BoNT-A injections significantly reduced the severity of erythema in patients with rosacea. BoNT is also used in treating anal fissure, Raynaud Phenomenon, androgenetic alopecia (AGA), plaque psoriasis, inverse psoriasis, and Hailey-Hailey disease. In the case of AGA, two studies showed promising results with BoNT treatment, with one showing a significant increase in hair count after 24 weeks. BoNT-A has also been effective in treating conditions like Hailey-Hailey disease, eccrine nevus, oily skin, pompholyx, Darier’s disease, hypertrophic scars, and primary hyperhidrosis. However, more research is needed in many cases, and potential side effects of BoNT-A, such as pharyngitis and flu-like syndrome, are mentioned.
