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Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

72 citations, November 2012 in “PloS one”

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

research Defining the Cellular Environment in the Organ of Corti Following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea

71 citations, January 2012 in “PloS one”

The conclusion is that genetic differences affect how the cochlea heals after hair cell loss, which may challenge the creation of hearing loss treatments.

Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

research Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

68 citations, May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

research Beta-Caryophyllene Enhances Wound Healing Through Multiple Routes

67 citations, December 2019 in “PloS one”

Beta-caryophyllene helps improve wound healing in mice, especially in females.

research Two Hydroxyproline Galactosyltransferases, GALT5 and GALT2, Function in Arabinogalactan-Protein Glycosylation, Growth, and Development in Arabidopsis

63 citations, May 2015 in “PloS one”

GALT5 and GALT2 are important for plant growth and development because they help with protein glycosylation.

Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

research Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

62 citations, March 2015 in “PLOS ONE”

Pre-seeding scaffolds with fibroblasts improves skin wound healing.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations, April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations, July 2011 in “PLOS ONE”

Spermidine may help reduce hair loss and deserves further testing as a treatment.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations, January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

research Selective Androgen Receptor Modulators Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial-Mesenchymal Stem Cell Signaling

56 citations, July 2014 in “PloS one”

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations, February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

research Transcriptome Profile at Different Physiological Stages Reveals Potential Mechanism for Curly Fleece in Chinese Tan Sheep

55 citations, August 2013 in “PloS one”

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations, May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations, February 2012 in “PloS one”

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

research Long-Term Differential Changes in Mouse Intestinal Metabolomics After Gamma and Heavy Ion Radiation Exposure

50 citations, January 2014 in “PLOS ONE”

Heavy ion radiation has a more severe and long-lasting effect on mouse intestinal metabolites than gamma radiation.

research Scalp Bacterial Shift in Alopecia Areata

48 citations, April 2019 in “PloS one”

Alopecia areata patients have more Propionibacterium acnes and less Staphylococcus epidermidis on their scalps.

research Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

48 citations, May 2015 in “PLOS ONE”

DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.

research Of PCOS Symptoms, Hirsutism Has the Most Significant Impact on the Quality of Life of Iranian Women

48 citations, April 2015 in “PLOS ONE”

Excessive hair growth affects the quality of life of Iranian women with PCOS the most.

research C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

48 citations, March 2010 in “PloS one”

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations, April 2014 in “PLOS ONE”

Gray hair may be caused by lower antioxidant activity in hair cells.

research Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations, September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

44 citations, March 2015 in “PLOS ONE”

Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.

A Powerful Method for Pleiotropic Analysis Under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer

research A Powerful Method for Pleiotropic Analysis Under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer

43 citations, December 2020 in “PLOS Genetics”

New method finds genetic links between Type 2 Diabetes and Prostate Cancer not seen before.

research The Role of Medical Language in Changing Public Perceptions of Illness

43 citations, December 2008 in “PLOS ONE”

Medical terms make new health issues seem more serious but don't affect views on well-known conditions.

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations, March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

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