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Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Stem cell niches support, regulate, and coordinate stem cell functions.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Latanoprost can make eyelashes longer, thicker, and darker.

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Male pattern baldness involves genetics, hormones, and needs better treatments.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Estrogen therapy can reduce skin aging but has cancer risks.

Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Too much androgen can cause hair loss; finasteride may help.

Understanding hair follicle anatomy helps diagnose hair disorders.

Minoxidil promotes hair growth in male pattern baldness.