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    Glossary Pigmented Hair Follicles

    structures in skin producing hair with melanin pigment

    Pigmented hair follicles are the structures in the skin that produce hair containing melanin, the pigment responsible for hair color. These follicles have active melanocytes, which are cells that synthesize and transfer melanin to the hair shaft, giving it its characteristic color, whether it be black, brown, blonde, or red.

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    1. Interaction of Minoxidil with Pigment in Cells of the Hair Follicle: An Example of Binding without Apparent Biological Effects Skin Pharmacology and Physiology · 1992 · 7 citations
    2. Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation Experimental and Therapeutic Medicine · 2017 · 6 citations
    3. Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage ˜The œFASEB journal · 2006 · 210 citations
    4. Hair follicle stem cells: Walking the maze European Journal of Cell Biology · 2007 · 165 citations
    5. The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles International Journal of Radiation Biology · 2015 · 5 citations
    6. The effect of flavonoids on regenerated hair follicles with pigmentation Journal of Dermatological Science · 2017
    7. The Hair Follicle as a Dynamic Miniorgan Current Biology · 2009 · 759 citations
    8. Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice International Journal of Radiation Biology · 2013 · 6 citations
    9. All-trans retinoic acid induced the differentiation of amelanotic melanocytes of human hair follicle Linchuang pifuke zazhi · 2004
    10. Reconstructing hair follicle pigmentary unit using organoids and bioprinting International Journal of Bioprinting · 2026
    11. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011 · 260 citations
    12. Effect of intense pulsed light treatment on human skin<i>in vitro</i>: analysis of immediate effects on dermal papillae and hair follicle stem cells British Journal of Dermatology · 2013 · 6 citations
    13. The hair follicle enigma Experimental Dermatology · 2017 · 25 citations
    14. Life of the B10 Mouse: A View from the Hair Follicles and Tissue Stem Cells Cells tissues organs · 2023
    15. Alopecia Areata: A tissue specific autoimmune disease of the hair follicle Autoimmunity Reviews · 2005 · 185 citations
    16. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008 · 115 citations
    17. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013 · 41 citations
    18. Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis The EMBO Journal · 2021 · 25 citations
    19. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth PloS one · 2012 · 10 citations
    20. Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay” Experimental Dermatology · 2018 · 5 citations
    21. The distribution of melanocytes and the degradation of melanosomes in fetal hair follicles Micron · 2019 · 4 citations
    22. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    23. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    24. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    25. 576 A preliminary study of melanogenic markers in the differentiation of the human hair follicle melanin unit 2022
    26. Age-Related Hair Pigment Loss Current problems in dermatology · 2015 · 20 citations
    27. Hair melanocytes as neuro-endocrine sensors—Pigments for our imagination Molecular and cellular endocrinology · 2005 · 43 citations
    28. Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells Nature Protocols · 2022 · 39 citations
    29. Facial hyperpigmentation caused by pigmented demodicosis JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2025
    30. Cultured follicles offer hope for beating baldness Nature · 2013