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The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Different types of stem cells and their environments are key to skin repair and maintenance.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Flutamide rarely causes liver toxicity in prostate cancer patients.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Fullerenes show potential in skin care but need more safety research.

Eating the right nutrients can improve hair health, but taking extra supplements usually doesn't help unless you have a deficiency.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Treatments for permanent hair loss from scarring aim to stop further loss, not regrow hair, and vary by condition, with partial success common.

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Treatments for melanin disorders exist, but more effective options needed.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.