This letter challenges Dr. Dubois' statement that nearly all patients with Raynaud phenomenon will develop a systemic disorder, arguing that many experience it without progressing to serious disease.
31 citations
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January 2014 in “Clinical Endocrinology” This study found no significant differences in metabolic characteristics between different phenotypes of PCOS or between women with PCOS and healthy controls among reproductive-aged Iranian women.
January 2013 in “Journal of dermatology” This letter to the editor raises the possibility of a new medical entity characterized by symptoms such as poikiloderma, hyperpigmentation, alopecia, malformed bones, lymphedema, and decreased cortisol, but provides no clinical results.
This correspondence suggests that while patients with Raynaud phenomenon may develop connective tissue disorders, physicians should consider this possibility without assuming for certain that progression will occur.
November 2022 in “International Journal of General Medicine” This study found that non-alcoholic fatty pancreas disease is significantly more prevalent in women with polycystic ovary syndrome, and is associated with metabolic syndrome, insulin resistance, and hyperandrogenism.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” In this observational study, researchers found that 55% of participants with hair loss known as Khalitya had serum calcium deficiency, which aligns with both Ayurvedic and modern perspectives linking poor nutrition to hair disorder, highlighting the importance of dietary regulation and stress management.
4 citations
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September 2013 in “Expert Review of Endocrinology & Metabolism” Different types of polycystic ovary syndrome show varying levels of insulin resistance, with the 'PHO' type being the most insulin resistant.
4 citations
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December 2002 in “Gynecological Endocrinology” This review discusses the role of ovarian steroids in skin and hair metabolism, and suggests estrogens could slow skin aging post-menopause, while minoxidil is effective for women's hair loss.
January 2024 in “Asian Journal of Medical Sciences” In this study, researchers in South India observed that dermoscopic features like hair diameter diversity and miniaturized hair were common in female pattern hair loss, with yellow dots and honeycombing indicating more advanced stages, highlighting dermoscopy's utility in diagnosing and differentiating FPHL early.
1 citations
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October 2014 in “Journal of the American Geriatrics Society” This report describes a case of a 75-year-old woman whose diagnosis of hypopituitarism led to significant weight gain and improved physical function with treatment, highlighting the potential for overcoming frailty when investigating underlying causes in elderly patients.
September 2026 in “International Journal of Innovative Technologies in Social Science” This review discusses the relationship between physical activity and skin aging, highlighting that regular moderate exercise may benefit skin health but excessive exercise could increase oxidative stress and damage.
7 citations
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August 2019 in “Endokrynologia Polska” This study reported that women with metabolic PCOS phenotype have free androgen index values approximately twice as high as those with the reproductive phenotype.
1 citations
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December 2023 in “Curēus” This study observed that five out of fourteen individuals aged 13-16 years, who were homozygous for the p.C282Y mutation related to hemochromatosis, had increased liver and phlebotomy-mobilized iron levels.
January 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This abstract discusses the FitSpresso weight loss supplement's potential benefits and mechanisms but provides no clinical research findings; it reports on its ingredients and consumer ratings instead.
167 citations
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January 2006 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome reported a poorer health-related quality of life compared to women in the general population and patients with other medical conditions.
August 2008 in “European Neuropsychopharmacology” This study identified significant correlations between self-esteem, psychiatric symptoms, and health-related quality of life in peritoneal dialysis patients.
August 2021 in “Case Reports” This report describes a case where a woman with frontal fibrosing alopecia initially presented with symptoms resembling rosacea, but further investigation led to a diagnosis of FFA, resulting in a treatment change to oral finasteride and hydroxychloroquine.
1 citations
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January 2017 in “Spectrum Research Repository (Concordia University)” This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.
3 citations
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June 2019 in “Clinical nursing studies” In this study, the researchers reported that polycystic ovary syndrome negatively impacts the quality of life for women due to associated phenotypic characteristics like obesity and hirsutism.
1 citations
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April 2022 in “AACE clinical case reports” This case report describes a 36-year-old Pakistani phenotypic female diagnosed with 46,XY 5-alpha-reductase deficiency, highlighting that such disorders of sexual development can manifest with symptoms like obesity, hirsutism, and amenorrhea later in life due to unique circumstances.
January 2025 in “Diagnostics” In this prospective case-control study, researchers found that women with any phenotype of polycystic ovary syndrome exhibited increased retinal nerve fiber layer and choroidal thickness compared to healthy controls, with changes correlated to body mass index.
11 citations
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March 2021 in “Reproductive Biology and Endocrinology” This study found that bloating is the most frequently reported symptom and a main predictor of polycystic ovary syndrome among women using the Flo app across five countries.
40 citations
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January 2013 in “International journal of trichology” This study found that among women with frontal fibrosing alopecia, 100% showed dermoscopic elements suggestive of the condition, with perifollicular erythema often indicating disease activity.
September 2016 in “Springer eBooks” This review discusses how physical appearance, including skin, facial features, and physique, is linked to aging and health risks, but reports no new experimental results.
July 2025 in “Journal of Investigative Dermatology” Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.
December 2025 in “IntechOpen eBooks” This source critically examines the limitations of using BMI to assess obesity in women, especially during reproductive, pregnancy, and postmenopausal stages, and discusses more precise alternative methods for evaluating obesity in line with sex-specific healthcare needs.
February 2024 in “Skin research and technology” The researchers in this study identified molecular mechanisms involved in frontal fibrosis alopecia, highlighting immune response and fatty acid metabolism, and developed a four-gene diagnostic model showing high accuracy in distinguishing affected individuals from controls.
2 citations
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April 2022 in “African Health Sciences” In this study, FLI was significantly higher in women with PCOS and NAFLD compared to those without NAFLD, and an FLI < 30 could not effectively rule out NAFLD in lean PCOS patients.
145 citations
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March 2010 in “Fertility and Sterility” This study reported that ovulatory PCOS is a milder form of the condition compared to classic PCOS phenotypes, which share similar clinical and hormone characteristics.
32 citations
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April 2016 in “Journal of Obstetrics and Gynaecology Research” This study found that women with polycystic ovary syndrome phenotypes A and B had the highest prevalence of metabolic syndrome, and that the visceral adiposity index may help predict metabolic risk.