TLDR The Fatty Liver Index (FLI) may not be enough to rule out non-alcoholic fatty liver disease in lean women with polycystic ovary syndrome.
The study conducted from January 2014 to January 2016 involved 83 premenopausal women with polycystic ovary syndrome (PCOS) and 58 controls to investigate the predictivity of the Fatty Liver Index (FLI) for non-alcoholic fatty liver disease (NAFLD) in lean and overweight/obese females with PCOS. The results showed that γ-glutamyl transferase levels were significantly higher in females with PCOS than in the controls (p = 0.001), and FLI was significantly higher in females with NAFLD compared to those without NAFLD (47.1 ± 33.6 vs. 16.9 ± 21.6; p = 0.001). Body Mass Index had the strongest relationship with FLI in the PCOS group (p < 0.05, r = 0.908). Lean females with PCOS had a significantly higher rate of NAFLD (27.5% vs. 8.8%; p = 0.041) than lean controls. The study concluded that an FLI < 30 was not sufficient to rule out NAFLD in lean PCOS patients.
90 citations,
February 2013 in “The Journal of Clinical Endocrinology and Metabolism” Women with PCOS have more body fat and thicker fat layers in certain abdominal areas than women without PCOS.
45 citations,
January 2013 in “Journal of Human Reproductive Sciences” Women with PCOS are more likely to have fatty liver disease, especially if they have metabolic problems.
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4025 citations,
December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
119 citations,
November 2009 in “Human Reproduction” Women with PCOS and higher androgen levels are more likely to have fatty liver disease.
28 citations,
November 2019 in “Frontiers in Endocrinology” Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.
9 citations,
February 2022 in “Genes” Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.
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35 citations,
May 2015 in “Arquivos De Gastroenterologia” Women with PCOS are more likely to have fatty liver disease and worse metabolic health.
45 citations,
February 2012 Obese women with PCOS are more likely to have fatty liver disease.
62 citations,
October 2019 in “Liver International” Women with PCOS have more severe liver disease.
