research Perfectionism and Baldness Distress in Men
Men who are perfectionists feel more upset about baldness, partly due to aging anxiety.
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research Why Some Women Look Young for Their Age
Women look young for their age due to larger lips, less sun damage, and genes that prevent gray hair and wrinkles.
research Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study identified Type XVII collagen (COL17) as a crucial regulator of epidermal cell proliferation in the interfollicular epidermis (IFE) of both neonatal and aged mice. In neonatal mice, the absence of COL17 led to transient hyperproliferation due to disrupted Wnt signaling, which was reversible by replenishing COL17. In aged skin, loss of COL17 caused by inactive atypical protein kinase C signaling resulted in hyperproliferation, which could be suppressed by overexpressing human COL17. The research highlighted COL17's role in maintaining skin homeostasis and suggested its potential as a target for anti-aging treatments. However, the study faced limitations, including discrepancies between in vitro and in vivo results and a small sample size of patients with COL17A1 mutations, indicating a need for further investigation.
research Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study investigated the role of Type XVII collagen (COL17) in the interfollicular epidermis (IFE), focusing on its potential as an anti-aging molecule and its regulation of proliferation through Wnt signaling. It was found that loss of COL17 led to hyperproliferation and altered Wnt signaling, with aging also reducing COL17 levels and causing similar effects. However, reviewers noted concerns about the strength of the link between Wnt signaling and the observed phenotype, the transient nature of hyperproliferation in mice compared to humans, and speculative discussions on COL17's role in oncogenesis. Discrepancies between in vivo and in vitro findings were highlighted, and further validation was suggested to clarify these observations before publication.
research Decision letter: Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study examined the role of Type XVII collagen (COL17) in the regulation of interfollicular epidermis (IFE) homeostasis and its connection to Wnt signaling, with implications for skin aging. It found that COL17 deficiency led to transient hyperproliferation in neonatal mice, which decreased over time, and suggested a potential anti-aging role for COL17. However, the study faced criticism for the weak link between Wnt signaling and the observed phenotype, the transient nature of hyperproliferation, and discrepancies between in vivo and in vitro findings. Despite its high quality, the study required further validation and additional experiments to strengthen its conclusions and clarify the role of COL17 in preventing oncogenesis.
research A Mechanical Model of Overnight Hair Curling
Longer time setting curls overnight leads to better curl retention.
research Association Between Smoking and Hair Loss: Another Opportunity for Health Education Against Smoking?
Smoking may contribute to hair loss in men.
research Chapter 4: Cytomechanics of Hair
Hair's strength and flexibility come from its protein structure and molecular interactions.
research Androgenetic, Diffuse, and Senescent Alopecia in Men: Practical Evaluation and Management
The conclusion is that treatments like finasteride and minoxidil can prevent baldness progression and improve hair density, but more research is needed on other therapies.
research Male Androgenetic Alopecia
research Hormonal and Genetic Etiology of Male Androgenetic Alopecia
research Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart
The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.
research Older Women's Negative Psychological and Physical Experiences with Injectable Cosmetic Treatments to the Face
Older women reported negative physical and psychological effects from Botox and facial fillers, feeling neglected by the medical system.
research Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice
Mitochondrial therapy and platelet-rich plasma therapy both stimulated hair regrowth in aging mice, with mitochondrial therapy showing similar effectiveness to plasma therapy.
research Aesthetic Strategies for the Aging Asian Face
The document suggests using fat grafting and laser therapy to improve the aging Asian face and hair restoration techniques tailored to Asian hair characteristics, emphasizing natural results and cultural sensitivity.
research Autoimmune Diseases and Acquired Von Willebrand Disease in Two Cases of Progeria
Premature aging increases the risk of immune problems and autoimmune diseases.
research Dermatologic Problems of Older Women
Older women face various skin issues like dryness and thinning, and treatments are available but can have side effects; proper skin care and legal health decisions are important.
research Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome
Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.
research Contents
Men's facial rejuvenation involves unique challenges and is increasingly popular, with many opting for nonsurgical treatments.
research Mucosal TLR5 Activation Controls Healthspan and Longevity
Activating TLR5 in the gut can extend lifespan and improve health in aged mice.
research Reversing Wrinkled Skin and Hair Loss in Mice by Restoring Mitochondrial Function
Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.
research Evolution of Hair Restoration Surgery: Donor Dominance and Follicular Unit Transplantation
Hair restoration surgery redistributes existing hair to achieve a natural look, with visible regrowth in 3-4 months and rare complications, mostly aesthetic.
research Kalya Research: Complementary and Alternative Medicine Virtual Research Assistant from Biomedical Literature
Kalya Research is an AI tool that effectively finds and analyzes alternative medicine literature, saving researchers time.
research Therapeutic Effects of Stem Cells in Different Body Systems: A Comprehensive Review
Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.
research Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8)
Eating barley for life may lead to healthier aging in mice.
research Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors
Healthy lifestyle changes can significantly improve skin health as you age.
research Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors
Healthy habits like good diet, sleep, exercise, and socializing can greatly improve skin health as you age.
research Appearance and Internal Aging
Looking older on the outside might be linked to aging faster on the inside and can be affected by lifestyle choices and health risks.
research The Aging Face
Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.
research Clinical and Instrumental Characterization of Hair and Scalp Aging in Nonbalding Caucasian Women
Aging significantly affects the hair and scalp of nonbalding Caucasian women, with changes that differ from male pattern baldness.