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This study suggests that mutations in exon 10 of the POC1A gene may be linked to a distinct clinical condition characterized by extreme insulin resistance and short stature, differing from SOFT syndrome.

This study found that the absence of vitamin D receptor-mediated suppression of PPARγ expression causes hair loss in VDR-null mice.

This study found that Botryococcus terribilis ethanol extract significantly reduced inflammation markers in LPS-stimulated RAW264 cells, potentially via Axl inhibition and alteration of immune-related gene expression.

Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.

Paclitaxel chemotherapy causes premature aging and damage to hair follicles, potentially leading to permanent hair loss.

In this pilot study, minoxidil-treated scalp skin grafts from hair loss patients on mice showed increased expression of key anti-aging biomarkers and hair regrowth, suggesting minoxidil as a potential anti-aging agent by boosting VEGF-A production in hair follicles.

This study found that topically applied melatonin exerts significant anti-aging effects on human scalp skin ex vivo, including increased SIRT1 expression and reduced mTORC1 pathway activity.

Taxane chemotherapy can cause permanent hair loss by damaging hair follicles and altering their DNA.

This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.

This study found that GPC1 is a key regulator of angiogenesis in human dermal microvascular endothelial cells, influenced by factors secreted by keratinocytes, and may be a target for alopecia treatment research.

This study found that GPC1 plays a crucial role in regulating angiogenesis in human dermal microvascular endothelial cells, which may make it a potential target in alopecia treatment research.

This study identified a crucial role for epidermal Pgc-1α in regulating NAD+ signaling and influencing skin repair, with its dysfunction contributing to age-related wound healing defects.

This study found that GPC1 is a significant regulator of angiogenesis in human dermal microvascular endothelial cells, suggesting its potential as a target for alopecia research.

This study discovered that calcium dependent protein kinase 1 (CPK1) directly activates cyclic nucleotide-gated channels 5, 6, and 9, promoting root hair growth in Arabidopsis by regulating Ca²⁺ signaling.

This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.

This study found changes in the PGI2 pathway, especially in gene and protein expression, in diabetic mice, but did not observe PGI2-dependent vasomotor dysfunction.

This study found that GPC1 is a crucial regulator of angiogenesis in human dermal microvascular endothelial cells, indicating its potential as a target for treating alopecia.

This study describes GPRC5D's unique expression pattern in tissues that produce hard keratin, with retinoic acid inducing its expression in hair bulb cells and affecting keratin gene regulation.

In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.

AGC2-1 protein is essential for root hair growth in Arabidopsis.

This study found that four days of simulated night shift work in healthy adults reduced insulin sensitivity, suggesting a potential increased risk of type 2 diabetes.

This review compiles data on how the apelinergic system may protect against heart damage caused by doxorubicin cancer treatment, suggesting its potential to mitigate cardiotoxicity, though further research in chronic models is needed to confirm these effects and mechanisms.

This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.

In this study, Gsdma1/2/3 knockout mice showed reduced epidermal hyperplasia and inflammation when induced by PMA, which was attributed to decreased EGFR-Stat3/Akt signaling due to a decrease in related ligands.

This study suggests that cedrol may improve mitochondrial function, gut microbiota, and intestinal barrier integrity, indicating its potential value in treating inflammatory bowel disease.

This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets.

GNPTAB gene is crucial for normal hair color in humans and mice.

This study reports that the peptide GPIGS, found in Bacillus sp. M18 conditioned medium, may promote hair growth through the PI-3K/Akt pathway and accelerate hair regrowth in mice.

This study found that overexpression of PKCα in mouse epidermis increases expression of specific proinflammatory mediators and induces inflammation but does not significantly affect epidermal differentiation, proliferation, or tumor promotion with TPA.

This study found that overexpression of the metabolic enzyme PHGDH can promote cancer initiation and progression, highlighting its significant role in tumor cell proliferation and tumorigenesis.