Datasheet 1
December 2021
TLDR GPC1 is important for hair growth by helping blood vessels form around hair follicles.
The study investigated the role of glypican-1 (GPC1) in hair follicle angiogenesis, focusing on its interaction with growth factors like VEGF and HGF. GPC1 was found to be a significant co-receptor for VEGFR2 and c-Met, crucial for pseudotube formation in human dermal microvascular endothelial cells (HDMECs). The research showed that GPC1 enhanced the effects of VEGF and HGF, with HGF having a stronger pro-angiogenic effect. The study highlighted the potential of GPC1 as a target for addressing alopecia, as it played a key role in hair follicle microvascularization, which could impact hair miniaturization. The study involved multiple experiments with replicates, but the exact number of participants or samples was not specified.
