Image 1 TIF
December 2021
TLDR GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.
The study explored the role of glypican-1 (GPC1) in hair follicle angiogenesis, focusing on its interaction with growth factors like VEGF and HGF secreted by keratinocytes of the outer root sheath (KORS). GPC1 was found to be crucial in enhancing vascularization, acting as a co-receptor in angiogenesis, and significantly influencing human dermal microvascular endothelial cell (HDMEC) behavior. The research demonstrated that GPC1 promoted HDMEC proliferation, migration, and pseudotube formation through the HGF/c-Met and VEGF/VEGFR2 pathways. The study concluded that GPC1 played a vital role in hair follicle microvascular remodeling, suggesting its potential as a target for treating alopecia. Further research was recommended to explore the role of GPC1 glycosaminoglycan chains in hair follicle vascularization.
