December 2025 in “Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi” In this experimental study on rats, the researchers reported that administering minoxidil did not have significant electrophysiological or histopathological effects on penicillin-induced epilepsy, although future studies with larger sample sizes are recommended for more definitive conclusions.
4 citations
,
November 2018 in “Journal of Pharmaceutical and Biomedical Analysis” This study found that a hydro-alcoholic extract of Roselle petals may reduce free radical production during UV-induced photodecomposition of antibiotics, potentially offering protective benefits for patients using similar topical antibiotics.
1 citations
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May 2019 in “PubMed” This report presents a case of a female with PCOS treated with metformin who developed hyperuricemia, severe joint and neurological pain, and later experienced a hypersensitivity reaction to benzathine benzyl penicillin.
35 citations
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January 2019 in “Clinics in Dermatology” This review discusses contemporary issues in syphilis diagnosis and management, emphasizing the importance of recognizing and addressing both biomedical and psychosocial aspects, but provides no new clinical results.
7 citations
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November 1977 in “JAMA” This case report describes group A streptococcal septicemia with monoarticular arthritis linked to an infected IUD, likely transmitted through sexual foreplay in a 28-year-old woman.
May 2019 in “Pakistan Journal of Pharmaceutical Sciences” This case report presented a female with PCOS treated with metformin who developed hyperuricemia, migraine, neurological and joint pain, and rheumatic fever, later showing a delayed hypersensitivity reaction to benzathine benzyl penicillin treatment.
13 citations
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June 2013 in “Actas Dermo-Sifiliográficas” This review details five cases of syphilitic alopecia, an uncommon symptom in syphilis affecting mainly men, emphasizing that dermatologists should be vigilant as it can appear as the sole symptom.
7 citations
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November 2006 in “Pediatric Dermatology” This article describes the first reported case of alopecia in a neonate with congenital syphilis.
1 citations
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May 2019 in “The Journal of Pediatrics” The baby's hair loss was due to congenital syphilis, which was treated with penicillin.
1 citations
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January 2013 in “Mayo Clinic Proceedings” This case study details a 31-year-old woman diagnosed with secondary syphilis that presented with chronic headaches and hair loss, ultimately attributed to neurosyphilis and alopecia syphilitica.
December 2020 in “Journal of clinical and investigative dermatology” This case study highlights the rare simultaneous presentation of syphilitic alopecia and neurosyphilis in a 61-year-old man, underscoring the importance of recognizing this combination for timely treatment.
82 citations
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May 2010 in “PLoS neglected tropical diseases” This study provides quantitative evidence that secondary syphilis is highly endemic in Cali, Colombia, and many untreated patients have high numbers of circulating Treponema pallidum spirochetes.
September 2025 in “Media Kedokteran Hewan” This study found that 90% of African pygmy hedgehogs at Golden Dhonje Farm in Bogor District were affected by potential zoonotic fungi, including Scopulariopsis sp. and Penicillium sp.
23 citations
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January 2001 in “Chemical & Pharmaceutical Bulletin” This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.
August 2023 in “Veterinary Science and Medicine Journal” In this case study, the researchers diagnosed a young male cat with dermatitis caused by a fungal infection, specifically identifying Penicillium and Aspergillus species, and observed improvement in symptoms following a two-week treatment with grisofulvin, chlorphenamine maleate, and fish oil shampoo.
32 citations
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July 2017 in “Dermatology practical & conceptual” This study is the first to describe a mixed pattern of essential syphilitic alopecia using trichoscopy, identifying features like tapered bended hairs and perifollicular hyperkeratosis in a patient without secondary syphilis symptoms.
7 citations
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January 2018 in “International Journal of Dermatology” Syphilis can cause hair loss without other symptoms and should be considered when diagnosing unexplained hair loss.
6 citations
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September 2011 in “Journal of the American Academy of Dermatology” This report describes a case of secondary syphilis with an unusual folliculocentric papular eruption in an HIV-positive patient, underlining the diagnostic challenges and importance of biopsy with treponemal staining in such cases.
4 citations
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March 2020 in “Berkala Ilmu Kesehatan Kulit dan Kelamin” This case report noted that HIV-infected men who have sex with men are at a higher risk of syphilis, requiring careful staging and prolonged serologic monitoring to assess treatment success.
2 citations
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December 2012 in “Acta Facultatis Medicae Naissensis” This article presents a case of syphilitic alopecia in a man, where treatment with benzathine penicillin G led to dramatic hair regrowth and resolution of syphilitic lesions within three months.
1 citations
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July 2024 in “Indian Journal of Sexually Transmitted Diseases and AIDS” In this study, a 38-year-old male with syphilis-related mixed pattern alopecia showed marked hair regrowth and resolution of postauricular lymphadenopathy after treatment with benzathine penicillin, suggesting that lymph node and hair examinations, along with trichoscopy, can aid in the diagnosis of alopecia syphilitica.
1 citations
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March 2024 in “Oxford Medical Case Reports” In this case study, researchers reported that moth-eaten alopecia was the only clinical sign of secondary syphilis in a 28-year-old man from Nepal, and treatment with Benzathine Penicillin G led to complete hair regrowth within four months.
April 2026 in “Frontiers in Medicine” This case study reports a 26-year-old male with secondary syphilitic alopecia misdiagnosed as alopecia areata, likely contracted through non-penetrative sexual contact. Effective treatment with intramuscular benzathine penicillin G led to complete hair regrowth within three months.
June 2025 in “British Journal of Dermatology” This case series observed the diagnostic challenges of secondary syphilis, highlighting diverse presentations such as rashes and systemic symptoms that can mimic other conditions, underscoring the importance of dermatological review, serological testing, and interdisciplinary care for effective treatment and management.
January 2025 in “The Pediatric Infectious Disease Journal” This report details a rare case of late latent syphilis in a 17-year-old male with unusual symptoms like polyarthritis and hair loss, which resolved following antibiotic treatment, highlighting varied syphilis presentations and the importance of STI screening, especially in high-risk groups.
January 2021 in “Our Dermatology Online” This case report discusses alopecia syphilitica in a young Belgian man, notes that hair loss was his only symptom, and highlights the improvement following penicillin treatment.
April 2015 in “Journal of the American Academy of Dermatology” This case study suggests that the most likely diagnosis for the patient with a pink, scaling rash is secondary syphilis.
16 citations
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April 1985 in “Archives of dermatology” This review discusses various treatments for pityriasis rubra pilaris, including vitamin A, methotrexate, and systemic steroids, reporting historical anecdotal evidence without new clinical results.
12 citations
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October 1976 in “The BMJ” This abstract reports an influenzalike illness with varying antibody titers observed in a woman and her husband, but it does not provide broader clinical findings.
11 citations
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May 2020 in “Anais Brasileiros de Dermatologia” This case report describes a patient with secondary syphilis exhibiting distinct dermoscopic features, including moth-eaten alopecia and an erythematous background more pronounced than previously reported.