research 194 An underlying mechanism of hair loss in acrodermatitis enteropathica
In this animal study, zinc deficiency in mice was linked to disrupted hair cycles and impaired hair regrowth, which were reversed by zinc supplementation.
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research Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation
This study found that CYP21A2 gene mutations are the most common cause of non-classic congenital adrenal hyperplasia, while CYP11B1 mutations are rare and may partially impair enzyme activity.
research 녹차의 에피갈로카테킨 갈레이트(EGCG) 활성기전이 신체 내·외적으로 미치는 영향에 대한 고찰
This review discusses the various biological activities of Epigallocatechin Gallate (EGCG) and its potential uses in cosmetics, food, and medicine, without reporting new clinical findings.
research Sponsored Lecture 2 : Global aspects of acne treatment: current & future benefits
This study highlights that the combination of adapalene and benzoyl peroxide (Epiduo®) is an effective first-line treatment for acne, significantly inhibiting antibiotic-susceptible and antibiotic-resistant P. acnes strains.
research A method on establishment of acne complex animal model
This study found that an acne complex animal model using rabbits showed more pronounced clinical symptoms and measured changes compared to the traditional Kligman model.
research P196 : Effects of different electrical parameter settings on hair growth: the changes of dermal papilla cell in vitro and at microscopic level in animal tissue
This study suggests that certain electrical settings may enhance hair growth by stimulating dermal papilla cell proliferation and increasing gene expression related to hair growth in vitro and in rabbit skin.
research 加齢性白質病変(leukoaraiosis)update (特集 あしたの脳梗塞)
This study found that saponin derivatives from P chinensis may effectively block CRH receptor function and could be used to treat stress-induced hair loss.
research Genetics of Alopecia
This review discusses recent genome-wide association studies identifying novel candidate genes for various forms of alopecia, providing insights into their pathogenesis and molecular mechanisms, but reports no new clinical results.
research Hair & Cutaneous Development
The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
research P62 Drug induced hypothyroidism in patients receiving treatment for multi-drug resistant tuberculosis
In this study, researchers reported that individuals from iodine-deficient regions have an increased risk of developing hypothyroidism from MDR-TB treatment regimens containing PAS and/or Prothionamide.
research News in brief
Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.
research 15. Hair and Nails
Women with androgenetic alopecia have fewer terminal hairs, phenol in nail surgery is safe, and a new hair transplant method is faster and less damaging.
research Novel Technique of Follicular Unit Extraction Hair Transplantation with a Powered Punching Device
This study found that the novel powered FUE (P-FUE) technique reduced harvesting time and graft transection rates in hair restoration compared to manual FUE, with broader patient applicability.
research Neurogenic skin inflammation in stress‐triggered inhibition of hair growth in mice is promoted via nerve growth factor‐dependent pathways
In this study, neutralizing nerve growth factor reduced stress-triggered hair loss in mice, suggesting that nerve-immune system interactions and neurogenic inflammation contribute to this condition.
research In This Issue
Hedgehog signaling is crucial for hair development, cadherins affect cell adhesion, neutrophils play a role in skin lesions, and BP230 autoantibodies impact skin stability.
research Festschrift in honor of the 65th birthday of Dr. Howard I. Maibach
Antiyeast treatments work better for seborrheic dermatitis than steroids, and other findings include increased skin bacteria under plastic wrap, a nasal cell defect in Staphylococcus aureus carriers, quick resolution of certain skin reactions, high rubber latex allergy in spina bifida patients, and glyceryl monopentadecanoate's effectiveness for male hair loss.
research Gene detection in a family with monilethrix and observation of the treatment effect with 5% topical minoxidil
This study found that a specific gene mutation was identified in a family with monilethrix, and treatment with 5% minoxidil liniment improved hair quality in the proband without adverse events.
research Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
This study investigated a finasteride and oregano oil-loaded nano-cubosome gel formulation, finding it enhanced drug release and skin permeation and demonstrated synergistic antibacterial effects, suggesting potential for treating alopecia areata.
research New developments in our understanding of acne pathogenesis and treatment
This review discusses recent advances in understanding acne pathobiology, highlighting the potential for developing new customized therapies, but it reports no new clinical findings.
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research Neuroimmunology of Stress: Skin Takes Center Stage
This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth
This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.
research Probing the Effects of Stress Mediators on the Human Hair Follicle
In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
research Hair follicle immune privilege and its collapse in alopecia areata
This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
research Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control
This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.
research Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin
This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.
research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin, and Hair Growth Modulation by Neuropeptides
This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.
research Somatosensory organization and behavior in naked mole‐rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain
In this study, naked mole-rats demonstrated unique skin and hair follicle innervation features compared to other species, suggesting adaptations to their subterranean environment and poikilothermy.
research Neural Mechanisms of Hair Growth Control
This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.
research The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives
This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.