P62 Drug-Induced Hypothyroidism in Patients Receiving Treatment for Multi-Drug Resistant Tuberculosis

    December 2011 in “ Thorax ”
    Janesh Gupta, R. A. M. Breen, Heather Milburn
    TLDR People from iodine-deficient areas are more likely to develop hypothyroidism when treated for multi-drug resistant tuberculosis.
    The study reported on five cases of multi-drug resistant tuberculosis (MDR-TB) treatment, where four patients developed drug-induced hypothyroidism, marking the largest cohort reported with this condition due to MDR-TB treatment. The patients, primarily from ethnic minorities and areas of iodine deficiency, were treated with regimens containing p-aminosalicylic acid (PAS) and Prothionamide. Symptoms included lethargy, goitre, and hair loss. Hypothyroidism developed between 101-442 days of treatment, with those from iodine-deficient regions developing it sooner and requiring longer for euthyroid resolution despite increased thyroxine therapy. The study concluded that individuals from iodine-deficient areas have a higher risk of developing hypothyroidism with these treatments, recommending regular monitoring of thyroid function tests (TFTs) in such patients.
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