5 citations
,
July 1998 in “PubMed” This article reviews androgenic disorders in women, such as PCOS, highlighting how understanding these conditions could improve their management, but it presents no new clinical findings.
14 citations
,
June 2011 in “Steroids” This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.
1 citations
,
September 2020 in “Endocrinology, Diabetes & Metabolism Case Reports” This case report describes a woman with hypertension, alopecia, and other symptoms, revealing that her condition was due to ovarian hyperthecosis, highlighting the overlap of adrenal and ovarian disorders.
January 2025 in “International Journal of Pharmaceutical Research and Applications” This review discusses the use of experimental animal models to better understand the poorly understood mechanisms behind polycystic ovarian syndrome and reports no new clinical results.
May 2023 in “The journal of sexual medicine” In this study, bilateral oophorectomy was reported as an effective treatment for normalizing androgen levels and resolving hypersexuality and related symptoms in a post-menopausal woman with ovarian hyperthecosis, suggesting its importance in addressing excess androgen production in such cases.
4 citations
,
December 1962 in “European journal of endocrinology” Alloxan diabetes, methylthiouracil, cortisone, and adrenaline affect how white mice hair follicles use glucose and cystine and their cell division.
27 citations
,
May 1976 in “PubMed” This study concluded that wedge resection in patients with polycystic ovary syndrome did not significantly affect androgen status or the biochemical features of the condition, though most regained regular menstrual cycles and some became pregnant.
6 citations
,
October 1993 in “Endocrinology” In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.
November 2021 in “Pharmaceutical Sciences” This study found that the compound androstane-17-carboxamide 6 may serve as a lead for new drugs to treat BPH and prostate cancer by reducing the weight of androgen-dependent glands.
This study found that while 11-oxyandrogens are linked to excess hair growth, they do not aid in diagnosing PCOS and require further research to determine their clinical utility.
January 2007 in “Yearbook of Dermatology and Dermatologic Surgery” Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.
30 citations
,
August 2019 in “Medical Sciences” This review summarizes evidence suggesting that excess androgens play a key role in the origins of polycystic ovary syndrome, highlighting opportunities for developing targeted treatments.
October 2023 in “Clinical case reports” This case study reports the first Palestinian case of an ovarian steroid cell tumor with virilization in a young female, highlighting the challenges in diagnosis and varied chemotherapeutic responses.
3 citations
,
August 2013 in “Maǧallaẗ ǧāmiʻaẗ al-anbār li-l-ʻulūm al-ṣirfaẗ” This study found that women with polycystic ovary syndrome had significantly lower levels of estradiol and follicle stimulating hormone compared to fertile women, with no significant differences in testosterone and thyroid hormone levels.
31 citations
,
November 2014 in “Investigative Ophthalmology & Visual Science” This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.
11 citations
,
January 2017 in “Skin Appendage Disorders” This study associated ivory-colored areas observed through trichoscopy with steroid deposits in the dermis among patients with steroid-induced atrophy on the scalp.
September 2021 in “Research Square (Research Square)” This study found that measuring specific steroid hormone levels can aid in diagnosing P450 oxidoreductase deficiency, a subtype of congenital adrenal hyperplasia, by distinguishing affected patients from healthy individuals.
September 1976 in “PubMed” This article discusses the causes and treatments for hirsutism, concluding that reverse-sequence therapy with cyproterone acetate and ethinyl estradiol is effective for severe cases but has cost and side effects.
June 2025 in “Medicine theory and practice” This study compared the effectiveness of combined oral contraceptives and antiandrogens for treating women with polycystic ovarian syndrome in late reproductive age.
5 citations
,
January 1984 in “Journal of psychosomatic obstetrics and gynecology/Journal of psychosomatic obstetrics and gynaecology” This study found that treatment with cyproterone acetate and ethinylestradiol in hirsute women reduced testosterone and androstenedione levels, decreased hair growth, and increased cortisol levels without changing catecholamine excretion.
December 2024 in “PubMed” This study evaluates the compatibility of six active pharmaceutical ingredients, including finasteride and spironolactone, with TrichoFoam™, a foam vehicle used in personalized treatments for alopecia, though it does not report specific results.
65 citations
,
October 2008 in “Journal of Neuroendocrinology”
10 citations
,
August 1998 in “Journal of Investigative Dermatology” This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.
May 2021 in “The FASEB Journal” This study presents the crystal structure of human SRD5A2 with finasteride and reveals insights into its enzyme catalysis and inhibition mechanisms, which may inform drug development.
January 2025 in “Case Reports in Dermatological Medicine” In this study, two female patients with severe, treatment-resistant alopecia areata showed significant hair regrowth after a single session of intradermal administration of adipose tissue–derived exosomes, without experiencing adverse events, suggesting a promising therapeutic strategy for refractory cases.
25 citations
,
September 1977 in “Journal of Toxicology and Environmental Health” This study in female beagle dogs found that long-term exposure to oral contraceptive steroids resulted in significant reproductive and mammary gland changes, with the relevance to human tumor risk remaining uncertain.
46 citations
,
September 2014 in “Steroids” This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.
65 citations
,
January 2011 in “Frontiers in Endocrinology” This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.
5 citations
,
November 2001 in “PubMed” This case report describes an 80-year-old woman with severe androgenic alopecia linked to Leydig cell hyperplasia in an ovarian cyst, highlighting the need to investigate androgen-secreting tumors in similar cases.
This report describes a complex case of postmenopausal hyperandrogenism with virilization and concurrent rare ovarian tumors, highlighting the critical role of interdisciplinary collaboration in diagnosing and managing such challenging scenarios.