Study on Changes of 19 Steroids in Plasma From 9 Diagnosed Patients With P450 Oxidoreductase Deficiency
September 2021
in “
Research Square (Research Square)
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → P450 oxidoreductase deficiency congenital adrenal hyperplasia pregnenolone 17-hydroxyprogesterone corticosterone 11-deoxycorticosterone 11-deoxycortisol 21-deoxycortisol androstenedione testosterone dihydrotestosterone dehydroepiandrosterone sulfate estradiol testosterone to dihydrotestosterone ratio PORD CAH DHT DHEA-S
Studysummary This study found that measuring specific steroid hormone levels can aid in diagnosing P450 oxidoreductase deficiency, a subtype of congenital adrenal hyperplasia, by distinguishing affected patients from healthy individuals. Our plain-language summary of this paper — not a Tressless recommendation.
The study focused on identifying steroid hormone biomarkers in plasma to diagnose P450 oxidoreductase deficiency (PORD) in congenital adrenal hyperplasia patients. Using liquid chromatography–tandem mass spectrometry, researchers measured 19 steroid hormones in 9 clinically diagnosed PORD patients (3 males, 6 females). Results showed significant increases in plasma levels of pregnenolone, 17-hydroxyprogesterone, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, and 21-deoxycortisol in PORD patients compared to controls. Male patients exhibited significantly lower levels of androstenedione, testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, and estradiol, while female patients showed significant differences in dihydrotestosterone and dehydroepiandrosterone sulfate levels. The study concluded that these hormones and the testosterone to dihydrotestosterone ratio are crucial markers for diagnosing PORD.
