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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that 11α-hydroxyprogesterone is a potent inhibitor of 11βHSD2 in vitro and may serve as a precursor to unique C11α-hydroxy steroids in prostate cancer tissue.

research Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency

5 citations , March 2013 in “BMJ case reports”

This case report suggests that Roux-en-Y gastric bypass may improve symptoms of non-classic adrenal hyperplasia related to 11-hydroxylase deficiency by reducing insulin resistance.

research MON-369 Treatment of Nonclassic 11-Hydroxylase Deficiency with "Hair, Skin, and Nails," an Over-the-Counter, Insulin Sensitizing Vitamin/Mineral Supplement

April 2019 in “Journal of the Endocrine Society”

This case report suggests that a supplement containing biotin, beta carotene, vitamin C, zinc, and copper may improve insulin resistance markers and hair loss in a patient with non-classic 11-hydroxylase deficiency.

A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia among Women Presenting with Hyperandrogenic Symptoms and Signs

150 citations , November 2007 in “The Journal of Clinical Endocrinology and Metabolism”

This study determined that nonclassical congenital adrenal hyperplasia has a 2.2% prevalence among hyperandrogenic women in Spain, with basal serum 17-hydroxyprogesterone showing excellent diagnostic performance.

Influence of Sex and Functional Status on the Value of Serum Steroid Profiling in Discriminating Adrenocortical Carcinoma from Adrenocortical Adenoma

research Influence of sex and functional status on the value of serum steroid profiling in discriminating adrenocortical carcinoma from adrenocortical adenoma

4 citations , September 2024 in “Frontiers in Endocrinology”

This study found that serum steroid profiling, particularly 11-deoxycortisol, can effectively differentiate between ACC and ACA, while considering sex differences and functional status for other steroids is important.

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community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community 11 months on topical minoxidil, and four months on topical finastride

11 upvotes 1 week ago

The conversation discusses hair loss treatments using topical minoxidil (5%) and topical finasteride, with no side effects reported. Users share application tips and express hope for regrowing hair, especially in the corners and temples.

community 11 months of progress on 1.25 fin only.

14 upvotes 4 weeks ago

The user experienced improved hairline results after 11 months on finasteride, with no significant side effects except temporary nipple sensitivity. They are considering adding minoxidil for better results but are waiting for full effects from finasteride.

community 11.5-month progress on Finasteride + Minoxidil (Topical → Oral). Looking for honest opinions on what’s still possible.

213 upvotes 2 months ago

OP experienced significant hair regrowth using 1 mg oral Finasteride and switched from topical to 2.5 mg oral Minoxidil, with concerns about miniaturized hairs near the hairline. OP plans to grow out their hair and is curious about future regrowth potential and hairstyle suitability.

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Learn

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learn Prednisolone

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

learn Desoximetasone

learn Hydrocortisone Butyrate

learn Hydrocortisone Valerate

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Clinics

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Hair Systems
Salon 11/18 Hair & Makeup StudioJacksonville, FL · US

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