Choice of Therapy in Patients with Polycystic Ovary Syndrome in Late Reproductive Age

    June 2025 in “ Medicine theory and practice ”
    В. В. Смирнов, Анна Борисовна Шаповалова, Рената Ринатовна Файзуллина, Владимир Станиславович Василенко, Юлия Борисовна Семенова, Людмила Витальевна Курдынко
    From the encyclopedia
    Bicalutamide →

    a nonsteroidal anti-androgen, most commonly used orally for women

    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

    Studysummary This study compared the effectiveness of combined oral contraceptives and antiandrogens for treating women with polycystic ovarian syndrome in late reproductive age.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The article discusses polycystic ovarian syndrome (PCOS), an endocrine-metabolic disorder affecting 4-15% of women of reproductive age, characterized by chronic anovulation, hyperandrogenism, and metabolic issues like insulin resistance. It highlights a study comparing the effectiveness of combined oral contraceptives (COCs) and antiandrogens (such as flutamide, bicalutamide, and cyproterone) in treating women with PCOS in late reproductive age. The study aims to address hyperandrogenism and associated symptoms, providing insights into therapeutic options for managing PCOS in this demographic.
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