research Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
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research What Does the Concept of the Stem Cell Niche Really Mean Today?
Stem cell niches support, regulate, and coordinate stem cell functions.
research Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing
Lowering testosterone speeds up wound healing in male mice.
research The Effect of Minocycline on the Metabolism of Androgens by Human Oral Periosteal Fibroblasts and Its Inhibition by Finasteride
Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.
research Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions
Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
research The PDGF/PDGFR Pathway as a Drug Target
The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
research Emerging Medication for the Treatment of Male Hypogonadism
New treatments for male hypogonadism are effective and should be personalized.
research Mitoxantrone
Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.
research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?
Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.
research RANK as a Therapeutic Target in Cancer
RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
research Effects of the Anti-Androgen Finasteride on 5α-Reduction of Androgens in the Presence of Progesterone in Human Gingival Fibroblasts: Modulatory Actions of the Alkaline Phosphatase Inhibitor Levamisole
Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
research Big Head? Bald Head! Skull Expansion: Alternative Model for the Primary Mechanism of Androgenetic Alopecia
The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.
research Menopause
The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.
research Anti-Inflammatory Loading of Cinnamaldehyde on Artificial Bone Scaffolds Against Bone Regeneration
Cinnamaldehyde helps bone healing initially but may slow healing later unless combined with DHT treatment.
research Hair Conditioners: Impact of Oral Supplements on Skin and Hair Health
Some nutrients and antioxidants may improve skin and hair health, but more research is needed to confirm these benefits.
research Congenital Adrenal Hyperplasia: A Comprehensive Review
The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.
research Skin Connective Tissue and Aging
Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.
research Oral Retinoids in Dermatology
Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
research A Review on Traditional Uses, Phytochemistry, and Pharmacology of Eclipta Prostrata (L.) L.
Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.
research Use of Silicon for Skin and Hair Care: An Approach to Chemical Forms Available and Efficacy
Silicon can improve skin and hair health, but more research is needed.
research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis
Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
research Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization
FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.
research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates
Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
research Engineering Cell-Derived Matrices: From 3D Models to Advanced Personalized Therapies
3D cell-derived matrices improve tissue regeneration and disease modeling.
research A Population-Based Study of the Risk of Osteoporosis and Fracture with Dutasteride and Finasteride
Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.
research Platelet-Rich Plasma in Dermatology and Aesthetic Medicine
PRP helps with skin, hair, and wound treatments but needs more research for standard use.
research Alpinia Zerumbet: A Review of the Chemistry, Quantity, and Pharmacological Properties of Selected Kavalactones
Shell ginger contains kavalactones that promote hair growth and have anti-cancer, anti-inflammatory, and anti-obesity effects.
research Assessment of Anti-Aging Effects of Oral Choline-Stabilized Orthosilicic Acid on Hair, Skin, and Nails: An Open Label, Non-Randomized Interventional Study
Taking choline-stabilized orthosilicic acid orally significantly improved hair, skin, and nail health without side effects.
research A WWP2–PTEN–KLF5 Signaling Axis Regulates Odontoblast Differentiation and Dentinogenesis in Mice
WWP2 is crucial for tooth development in mice.