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This review reports that hair follicles are dynamic neuro-immuno-endocrine organs with intrinsic signaling pathways, which play a crucial role in hair disorders like alopecia. It highlights emerging regenerative approaches targeting these pathways for hair restoration.

This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.

This study found that Krox20 is overexpressed in scar fibroblasts and may play a role in scar formation by upregulating genes involved in tissue remodeling and wound healing.

This study diagnosed a group of six girls with various ectodermal abnormalities, identifying cranio-skeletal malformations consistent with focal dermal hypoplasia (Goltz syndrome), and found heterozygous mutations in the PORCN gene in two children.

This study explored the molecular communication between hair matrix cells and dermal papilla cells in cashmere goats, revealing key ligand-receptor pairs and signaling pathways that facilitate intercellular crosstalk and potentially influence hair growth mechanisms.

This correspondence discusses eyebrow alopecia in the context of centrofacial trichoblastomatosis and reports no new clinical findings.

This study describes a new tissue culture method that successfully induces outer root sheath cells from hair follicles to differentiate into a multilayered epithelium with characteristics similar to normal interfollicular epidermis.

In this case study, a 62-year-old woman with ovarian hyperthecosis experienced normalization of elevated testosterone levels and improvement in hirsutism and hair loss following bilateral salpingo-oophorectomy.

This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.

This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.

This study describes the first case of female pseudohermaphroditism due to a novel homozygous glucocorticoid receptor gene mutation, indicating possible pre- and postnatal virilization in affected females.

This study found that HIF-P4H-2 function in FoxD1-lineage cells is crucial for normal hair follicle development and homeostasis in mice, implicating disrupted HIF, TGF-β, and Notch signaling pathways in associated defects.

This study found that under hypoxic conditions, hair follicle-associated pluripotent stem cells differentiated into cardiac muscle cells at a higher rate compared to normoxic conditions.

In this study, researchers found that caffeine can counteract stress-induced damage in ex vivo human androgenetic alopecia hair follicles, suggesting it may help prevent stress-related hair loss.

This research review highlights how hair cortisol concentration can reflect the activation of the stress-response system in farm, domestic, and wild animals, noting it correlates with factors like species, sex, age, and environmental conditions, which may influence stress and adaptation.

This study identified the distribution of keratin-associated proteins during cornification in the epidermis of reptiles, revealing unique structural characteristics in sauropsid keratin proteins compared to other vertebrates.

This review discusses the hair follicle cycle's complex regulation and highlights the potential for targeting catagen control in future therapies without presenting new experimental data.

This study reports two cases of central serous chorioretinopathy developing after intralesional corticosteroid injections to the scalp for alopecia areata, suggesting a potential association that warrants cautious use and monitoring for ocular complications.

This study found that hair cortisol levels in black-tailed prairie dogs, influenced by factors like predation risk and lactation, were associated with reproductive success, supporting the Cort-Adaptation hypothesis.

This study found that female patients with anorexia nervosa had lower hair cortisol concentration compared to healthy and psychiatric controls, which may be influenced by body mass index rather than anorexia-related endocrine changes.

In this study, researchers successfully generated hair follicle organoids using human induced pluripotent stem cells (hiPSCs) with collagen I as a microenvironment, demonstrating potential applications in hair regeneration, though fully human organoids require additional approaches.

This review discusses the prevalence and clinical impact of menstrual abnormalities, acne, and hirsutism in young women with Cushing's syndrome and reports no new clinical results.

This study suggests that cortisol measured in human hair can effectively reflect increased production for up to six months, but its retrospective accuracy may be limited due to rapid decline in levels.

This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.

This study suggests that prenatal infusion of epidermal neural crest stem cells may improve certain neural markers and reduce cortical injury in a mouse model of methylazoxymethanol-induced malformations.

Keratin gene clusters in humans and marsupials are similarly organized.

This classification proposal introduces a novel system for categorizing cutaneous adnexal cysts based on their origin in the folliculosebaceous unit and sweat glands, aiming to simplify and enhance understanding of these skin lesions.

This study concluded that qiviut cortisol can be used as a measure of HPA axis activity in muskoxen, with hair growth phase and body region affecting cortisol levels.