Who and How to Screen for Endogenous Hypercortisolism Among Young Women Presenting with Clinical Hyperandrogenism and/or Menstrual Abnormalities

February 2025 in “ Journal of Endocrinological Investigation ”

Francesco Ferraù, Ylenia Alessi, Federica Nista, Anna Roux, Diego Ferone, Emanuela Arvat

endogenous hypercortisolism Cushing's syndrome clinical hyperandrogenism menstrual abnormalities hirsutism polycystic ovary syndrome acne PCOS

Studysummary This review discusses the prevalence and clinical impact of menstrual abnormalities, acne, and hirsutism in young women with Cushing's syndrome and reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Approach to Androgen Excess in Women: Clinical and Biochemical Insights

14 citations , March 2022 in “Clinical Endocrinology”

This review outlines a diagnostic approach for identifying non-PCOS pathology in women with androgen excess, emphasizing the importance of clinical history and biochemical phenotyping but reports no new clinical results.

research Adult Female Acne: Clinical and Therapeutic Particularities

4 citations , December 2021 in “Experimental and Therapeutic Medicine”

This article describes adult female acne as a complex condition affected by genetic, hormonal, and environmental factors, with hormonal therapies highlighted as particularly valuable for treatment.

research Hirsutism in Women: Causes, Diagnosis, and Treatment Options

11 citations , August 2019 in “PubMed”

This review discusses the causes, evaluation, and treatment options for hirsutism in women, but reports no new clinical results.

research Endocrinology of Hirsutism: From Androgens to Androgen Excess Disorders

20 citations , January 2019 in “Frontiers of Hormone Research”

This paper reviews the endocrinological aspects of hirsutism, focusing on the role of androgens in excessive hair growth and the related disorders, without presenting new findings.

research Complications of Cushing's Syndrome: State of the Art

374 citations , May 2016 in “The Lancet. Diabetes & endocrinology”

This article reviews the clinical complications and increased mortality risks associated with Cushing's syndrome but does not present new clinical data; it emphasizes the need for prompt treatment to mitigate these risks.

research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

This review discusses hirsutism management guidelines, recommending androgen testing only for women with abnormal hirsutism scores and advocating for combined therapy approaches depending on severity and underlying conditions, but it reports no new clinical results.

research A Detailed Investigation of Hirsutism in a Turkish Population: Idiopathic Hyperandrogenemia as a Perplexing Issue

42 citations , October 2004 in “Experimental and Clinical Endocrinology & Diabetes”

In this study, PCOS was the most common cause of hirsutism among Turkish women, but about 17% had idiopathic hyperandrogenemia with no clear cause identified.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations , August 1994 in “Clinical Endocrinology”

In this study of women with hirsutism or androgenic alopecia, diverse underlying endocrine disorders including polycystic ovaries and various enzyme deficiencies were detected, often associated with elevated testosterone levels.