Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article proposes a new classification, the Obsessive-Compulsive Insight Continuum, to help dermatologists better understand and diagnose skin disorders with obsessive-compulsive features.

This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

This overview highlights the exploration of mesenchymal stromal cells as potential treatments for COVID-19, noting their regenerative and immunomodulatory properties for reducing ARDS severity in critically ill patients, but it provides no new clinical results.

This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.

This study found that topical minoxidil 5% foam was effective in promoting hair growth in both the frontal and vertex scalp for men with androgenetic alopecia.

This review discusses the onset of menstruation and related challenges in young women, with a focus on primary amenorrhea, its diagnosis, and management strategies, and reports no new clinical findings.

This study found that mice lacking the type 3 IP(3) receptor in their hair follicles experienced repetitive hair loss and regrowth, indicating disrupted hair-cycle regulation potentially linked to specific signaling pathways.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

This review discusses the potential link between long-term transdermal exposure to sex hormones from antiperspirants and increased breast and prostate cancer rates, calling for further research to confirm this theory.

In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.

This study found that compared to influenza patients, COVID-19 patients had fewer complications overall, but exceptions with higher risks were seen in hair loss, heart failure, mood disorder, and dementia.

This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.

This study found that neural crest-derived hair follicle cells in mice can differentiate into osteoblast-like cells, suggesting a potential application for bone regenerative therapies.

This study reports that epidermal neural crest stem cells from dogs (cEPI-NCSC) can generate neural crest derivatives and may offer a new cell-based therapy for canine spinal cord injury, with potential as a model for human treatments.

In this study, early treatment with nitazoxanide, ivermectin, or hydroxychloroquine, combined with azithromycin, was associated with reduced hospitalizations, respiratory complications, and deaths in early-stage COVID-19 patients compared to untreated controls.

This study found that health-related quality of life was significantly lower in women with polycystic ovary syndrome, especially those with the anovulatory phenotype, compared to non-PCOS controls attending a tertiary hospital.

In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.

This review discusses hypopituitarism's bidirectional relationship with COVID-19 due to metabolic comorbidities and pituitary risks, but it reports no new clinical results.

This study found that hair germ cells, derived from bulge stem cells, respond faster to dermal papilla signals and have limited proliferation compared to bulge cells during hair regeneration.

This study found that ephrin-A3 accelerates hair follicle development and increases hair follicle density in neonatal mice, suggesting its involvement in hair growth regulation.

In this study involving a mouse model, researchers reported that intranasal delivery of protein-based CRISPR/dCas9 nanoparticles targeting the gene *Sirt1* reduced cerebral edema and increased survival following ischemic stroke, with no significant toxicity observed.

This article reviews the role of exosomes in promoting axonal regeneration and discusses recent findings on how exosome-borne molecules might influence the PTEN-mTOR pathway in injured neurons; it reports no new experimental results.

In this animal study, researchers found that finasteride may offer neuroprotective benefits as a post-ischemic treatment for strokes in aged male rats, suggesting its potential as a therapeutic agent in this context.

This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.

This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.

This study found that finasteride impaired object recognition memory and altered hippocampal dendritic structures in male 3xTg-AD mice, suggesting potential sex differences in Alzheimer's disease pathology.

This study found that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, suggesting a novel signalling pathway in the skin.

This study tested the feasibility of using multimodal recruitment strategies to assemble a diverse group of 438 women for a web-based survey on ovulation and menstruation health, finding that internet and community fair methods achieved higher enrollment and completion rates compared to clinic recruitment.