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Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Fungi-produced compounds can change plant root growth.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Different types of stem cells and their environments are key to skin repair and maintenance.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.