February 2025 in “Journal of Cosmetic Dermatology” This case report describes a 34-year-old Asian female who experienced prolonged localized facial blanching following botulinum toxin type A injection, marking the first such documented case in this population.
52 citations
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January 2023 in “Toxins” This narrative review discusses expert consensus on the optimal use of botulinum toxin injections for cosmetic applications in facial and oral-maxillofacial areas across Asian and Caucasian populations, highlighting injection techniques, effective doses, historical context, and potential complications.
8 citations
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October 2005 in “Otolaryngologic Clinics of North America” This article discusses the mechanisms and prevention of aging, particularly in facial rejuvenation, but reports no new experimental findings.
January 2026 in “Microsystems & Nanoengineering” This study analyzed 853 articles to reveal that research on silica-based nanobiomaterials in regenerative medicine has rapidly increased, with distinct regional differences in impact and emerging focus areas in drug delivery and wound healing.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.
This study in adult mice found that somatosensory axons innervating Merkel cells in the skin are highly plastic, with significant remodeling in response to epithelial turnover, and that Merkel cells play a role in limiting axonal branching and promoting their maturation.
14 citations
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March 2015 in “Facial plastic surgery clinics of North America” This review discusses various surgical techniques for rejuvenating the aging upper face, focusing on the assessment of individual structures and their relationships, but it reports no new clinical results.
15 citations
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September 2018 in “Medicine” This review discusses the causes and clinical presentations of ptosis in childhood and reports on several observed cases, but provides no new clinical results.
This study found that somatosensory axons innervating Merkel cells in adult mouse skin exhibit significant plasticity, influenced by epithelial and neural factors, indicating a complex interaction in maintaining homeostasis.
This study observed a high degree of plasticity in somatosensory axons innervating Merkel cells in mouse skin, finding that both axons and Merkel cells underwent dynamic remodeling, with their interactions influencing axonal branching and maturation.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, revealing that both epithelial-neural crosstalk and intrinsic neural mechanisms contribute to axonal patterning and remodeling during epithelial homeostasis.
This study observed that Merkel cells and their associated somatosensory axons in mouse skin exhibit significant plasticity, remodeling dynamically to maintain homeostasis. Axonal branching patterns were notably influenced by Merkel cells, suggesting epithelial-neural interactions play a key role in axonal plasticity and patterning.
In this study, highly dynamic remodeling was observed in mouse somatosensory axons and Merkel cells, indicating that epithelial-neural interactions help maintain homeostatic remodeling, with additional intrinsic neural mechanisms contributing to axonal plasticity.
6 citations
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May 2019 in “JAMA Facial Plastic Surgery” In this study, procerus and corrugator myectomy techniques during browlifts significantly improved dynamic glabellar wrinkles compared to browlifts without muscle resection over 12 months.
3 citations
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December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.
4 citations
,
November 2020 in “Psoriasis : Targets and Therapy” This review discusses the complexities of managing adolescent psoriasis amidst challenges like identity formation and parent-adolescent dynamics, and proposes updated management strategies for 21st-century adolescents, but reports no new clinical results.
116 citations
,
September 2020 in “Nature Communications” This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.
36 citations
,
January 2014 in “Elsevier eBooks” This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.
3 citations
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July 2025 in “International Journal of Biological Sciences” This review highlights that the RNA modification N6-methyladenosine (m6A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.
December 2025 in “Frontiers in Immunology” This review highlights that disturbances in neuroimmune communication, particularly between sympathetic nerves and macrophages, may contribute to autoimmune diseases like rheumatoid arthritis and type 1 diabetes, and suggests potential therapeutic avenues by restoring this communication in preclinical and early clinical studies.
277 citations
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July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
260 citations
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December 2012 in “Cold Spring Harbor Perspectives in Biology” This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.
38 citations
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February 2016 in “Surgery Journal” This article discusses a wide range of procedures in facial plastic surgery and highlights the recent advancements and trends without reporting new clinical findings.
August 2025 in “Acta Biomaterialia” This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.
February 2026 in “Journal of Aesthetic Medicine” This narrative review concluded that facial aging involves complex anatomical changes that require multimodal rejuvenation approaches, integrating fillers, collagen stimulators, botulinum toxin, and energy-based devices for effective results, while emphasizing the need for scientific evidence and patient safety in aesthetic treatments.
26 citations
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February 2021 in “FEBS Journal” This review discusses potential immune therapies targeting regulatory T cells for age-related diseases and emphasizes the need for further research to translate these therapies into clinical practice.
1 citations
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February 2026 in “ACS Nano” This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.
1 citations
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March 2024 in “Nanomaterials” This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.
January 2026 in “Burns & Trauma” This review synthesizes evidence on how RNA modifications affect wound healing, particularly in skin, bone, and corneal injuries, emphasizing potential therapeutic strategies for burns and trauma in relation to these cellular processes.
2 citations
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.