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    A Multimodal Approach to Facial Rejuvenation: Integrating HA Fillers, Collagen Stimulators, Botulinum Toxin, and Energy-Based Devices for Optimal Patient Outcomes

    February 2026 in “ Journal of Aesthetic Medicine ”
    Jakov Jurcevic, Romana Čeović
    Studysummary This narrative review concluded that facial aging involves complex anatomical changes that require multimodal rejuvenation approaches, integrating fillers, collagen stimulators, botulinum toxin, and energy-based devices for effective results, while emphasizing the need for scientific evidence and patient safety in aesthetic treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. Platelet-Rich Plasma: Molecular Mechanisms, Actions, and Clinical Applications in the Human Body International Journal of Molecular Sciences · 2025
    2. Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model Lasers in Surgery and Medicine · 2025
    3. Advancements in Regenerative Medicine for Aesthetic Dermatology: A Comprehensive Review and Future Trends Cosmetics · 2024
    4. AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing Expert Opinion on Biological Therapy · 2021
    5. The Non-Neuronal and Nonmuscular Effects of Botulinum Toxin: An Opportunity for a Deadly Molecule to Treat Disease in the Skin and Beyond British Journal of Dermatology · 2017
    6. Cosmeceuticals: Peptides, Proteins, And Growth Factors Journal of Cosmetic Dermatology · 2016