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Cold gel compresses are the best for pain relief during scalp microneedling.

Light can be used to stimulate ear hair cells, improving speed and consistency over previous methods.

Smart microneedles using advanced tech could improve psoriasis treatment.

In this case report, the authors observed that onabotulinum toxin A therapy, extended to areas around traumatic excoriations and alopecia, resulted in notable healing and hair regrowth in a patient with trigeminal trophic syndrome and trichotillomania.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study found that using an electrical microneedling device enhanced the penetration of liposomal melanin-fluorescein into hair structures and widened the follicular infundibulum in ex vivo human skin models.

Botulinum toxins show promise in treating various conditions, but more research is needed for hair and scalp disorders.

This review reports that microneedle-mediated transdermal drug delivery systems show promise in enhancing alopecia treatments by improving the efficacy of various therapeutic agents, including drugs, biologics, and stem cells, but highlights a gap between basic research advancements and clinical trial focus.

Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.

This study suggests that hair follicle stem cells from transgenic mice can improve nerve regeneration and function, highlighting their potential as an autologous source for regenerative medicine.

This study demonstrated that a keratin gel promotes nerve regeneration across critical defects in rabbit models, showing improved nerve conduction and muscle action potential compared to control treatments.

This opinion article reviews various pathways through which onabotulinumtoxinA might work in medical treatments, highlighting applications beyond muscle paralysis, including pain inhibition and potential effects on hair loss and cancer cell apoptosis.

This systematic review found that interventions targeting neuropeptides and neurotransmitters, particularly melatonin, substance P, and oxytocin, show consistent evidence for anti-inflammatory, reparative, and psychodermatologic benefits, highlighting the potential of neurohormonal signaling as a therapeutic target in dermatology.

The researchers reported that using exosomes from hair follicle stem cells with acellular nerve allografts helped bridge facial nerve defects in rats and may match the effectiveness of autograft therapy.

This review concluded that non-surgical hair restoration methods, such as pharmacologic and regenerative therapies, are important for delaying or supplementing surgical treatments when used properly.

This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.

This report introduces a tissue-engineered nerve conduit combining hfNCSCs-derived neurons and acellular nerve grafts to potentially repair long-distance peripheral nerve injuries.

This study found that camphor and similar compounds depress neural activity in rat mechanoreceptors, suggesting that their effects may not be mediated through TRP channels.

This review discusses the multifaceted roles of neurotrophins, especially nerve growth factor (NGF), in the development and function of nociceptors and reports no new clinical results.

In this study, researchers found that adding zygomaticotemporal nerve blocks to supratrochlear and supraorbital nerve blocks in mesotherapy lowered pain significantly during and after the procedure for hair regrowth in alopecia patients.

This review summarizes recent advancements in therapies targeting botulinum neurotoxin, emphasizing human monoclonal antibodies and clinical research, but provides no new clinical findings.

This dataset supports a study suggesting that hair follicle neural crest stem cell-derived exosomes carrying miR-214-3p may promote neurite outgrowth and aid peripheral nerve regeneration in vitro and in vivo.

This study found that exosomes derived from hair follicle neural crest stem cells significantly promoted nerve regeneration in injured neurons, particularly when overexpressing miR-214-3p, which enhanced axon extension and motor function recovery in both in vitro and in vivo models.

The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.

This review discusses the application of active transdermal technologies in cosmetic devices for skin restoration and enhancement, reporting no new clinical results.

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.

This study examined the use of keratin gel as a filler in nerve guides for peripheral nerve regeneration in a rat sciatic nerve injury model.

This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.

This review highlights the potential of ultrasound-assisted gene therapy for tissue regeneration by improving gene delivery efficiency through techniques like microbubble-mediated sonoporation. The authors discuss its applications in musculoskeletal, cardiovascular, and neural regeneration, while addressing future challenges in optimizing this non-invasive approach for clinical applications.

This study found that in mice with alopecia areata, a single subcutaneous injection of botulinum neurotoxin serotype A significantly reduced hair loss and stimulated hair follicle regeneration.