The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-Derived Exosomes in the Repair of Peripheral Nerve Injury

This study explores the role of hair follicle neural crest stem cell-derived exosomes (hfNCSCs-Exos) in peripheral nerve regeneration, focusing on the microRNA miR-214-3p. The researchers found that hfNCSCs-Exos promote axon extension and nerve regeneration in both in vitro and in vivo models, with the most significant effects observed when miR-214-3p is overexpressed. In contrast, down-regulation of miR-214-3p resulted in outcomes similar to the control group. The study highlights the potential of miR-214-3p in enhancing neurite outgrowth and functional recovery, suggesting its importance in therapeutic strategies for nerve injuries.