Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, HDAC inhibitors promoted the differentiation of rat C6 glioma cells through the production of 5α‐reduced neurosteroids, enhancing serotonin-stimulated BDNF gene expression.

This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.

This study found that pyramidal neural precursors best grew neurites on matrigel, while neural stem cells differentiated directionally on aligned fibrin, suggesting the importance of biomaterial selection for cell culture.

This study suggests that inhibitors of steroidogenic enzymes may have therapeutic potential for certain behavioral disorders linked to dopaminergic hyperfunction, despite concerns about their endocrine impacts.

This study found that pediatric alopecia areata patients had significantly lower serum BDNF levels compared to healthy controls, which were associated with greater alopecia severity, higher depressive symptoms, and poorer quality of life.

This review discusses the role of neural crest stem cell-like states in adult neural crest-derived tissues, suggesting they may contribute to tissue repair by generating new cell types and activating repair programs.

This study found that dutasteride may offer neuroprotective effects on dopaminergic neurons in an animal model of early-stage Parkinson's disease, suggesting potential therapeutic use.

In this study, inhibition of neurosteroid synthesis after inducing status epilepticus in rats led to acute seizures and accelerated the onset of epilepsy, suggesting a role for δ-GABAR plasticity in epileptogenesis.

In this study, the authors review how epigenetic regulation influences the role of iPSC-derived neural stem/progenitor cells in spinal cord injury therapy, highlighting challenges in the cells' generation, differentiation, and transplantation, and the effect of therapeutic tools on these processes.

This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.

This study identified a small molecule that activates GLI1, suppressing neuroblastoma cell growth, which may aid in developing new treatments for high-risk neuroblastoma cases.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This study found that neonatal finasteride and allopregnanolone alterations were associated with anxiety-related behavior changes and impaired aversive learning in adult rats, potentially due to GABA(A) receptor system changes in the hippocampus.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study found that neurosteroids and benzodiazepines decrease network excitability in neuronal cultures, with specific long-term depressive effects on inhibitory neurons.

This study found extensive co-evolution of polyglutamine repeat lengths in neural protein clusters, highlighting their potential role in neurocognitive variation and neuropsychiatric disease development.

This review explores the role of neurosteroids in affective disorders, highlighting existing research on their impact on mood and discussing emerging evidence that endogenous neurosteroids may influence baseline emotional states.

This study found that patients with Bachmann-Bupp syndrome treated with DFMO showed improvements in hair growth, muscle tone, and development.

In this review, researchers examined advanced sensing technologies and bioelectronic interfaces that could improve understanding of the skin–brain axis, highlighting challenges and strategies for integrating these platforms into models for studying skin and neural interactions.

This study found that treating rat whisker follicle stem cells with retinoic acid and epidermal growth factor induced them to express synaptophysin, a marker of mature neurons, although there was a reduction in other neural markers, suggesting potential for neuro-regeneration applications.

This review examines emerging biomaterial strategies designed to support both neural regeneration and cutaneous wound healing, emphasizing their potential to improve sensory function through mechanisms like axonal regrowth and vascular network formation, while noting the need for standardized assessments and clinically translatable designs.

This study suggests that Sonic hedgehog from hair follicles may support the proliferation of dentate neural stem cells in mice through transport by platelets during the perinatal period.

This review highlights the roles of key transcription factors and signaling pathways in regulating olfactory epithelium regeneration, discussing recent advances in single-cell and spatial transcriptomics as well as organoid models to enhance understanding of olfactory regeneration mechanisms.

This case report describes a rare co-existence of Becker nevus and plexiform neurofibroma in a child with genetically confirmed neurofibromatosis type 1, offering insights into the potential cellular and molecular links between these lesions.

This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.