Assessment of Serum Level of Brain-Derived Neurotrophic Factor in Pediatric Alopecia Areata: A Case-Control Study

    September 2025
    Radwa Osama Mohamed Kamel, Amani Abdulaziz Mohammed Al-Kumaim, Alshaymaa A. Abd Elalim … Amany S. Amer
    Studysummary This study found that pediatric alopecia areata patients had significantly lower serum BDNF levels compared to healthy controls, which were associated with greater alopecia severity, higher depressive symptoms, and poorer quality of life.
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    Research cited in this study 9

    1. Evaluation of Quality of Life Scores and Family Impact Scales in Pediatric Patients with Alopecia Areata: A Cross-Sectional Cohort Study International Journal of Dermatology · 2024
    2. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    3. Serum Brain-Derived Neurotrophic Factor and Vitamin D: Two Concordant Players Controlling Depression Among Alopecia Areata and Vitiligo Patients: A Case-Control Study Journal of Cosmetic Dermatology · 2023
    4. Correlation Between Serum Brain-Derived Neurotrophic Factor Level and Depression Severity in Alopecia Areata Patients International Journal of Health Sciences · 2022
    5. Impact of Pediatric Alopecia Areata on Quality of Life of Patients and Their Family Members: A Nationwide Multicenter Questionnaire Study Annals of Dermatology · 2022
    6. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    7. All-Cause and Cause-Specific Mortality Risks Associated With Alopecia Areata JAMA dermatology · 2019
    8. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    9. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017