Unraveling the Complex: Changes in Secondary Science Preservice Teachers' Assessment Expertise

    January 2012 in “ ProQuest LLC eBooks ”
    Edward G. Lyon
    TLDR Changes in early neurosteroid levels can affect adult learning and anxiety.
    The study investigated the impact of altered neurosteroid levels during development on adult behavior in rats, focusing on the GABA(A) receptor system. Neonatal administration of allopregnanolone (AlloP) and finasteride, a 5alpha-reductase inhibitor, affected adult behavior, with finasteride leading to impaired passive avoidance retention and increased anxiety-like behavior. Intrahippocampal administration of pregnenolone sulfate (PregS) also disrupted passive avoidance, likely due to its anxiogenic effects. The findings suggested that fluctuations in neonatal AlloP levels influenced aversive learning and anxiety-related behavior in adulthood, potentially through changes in hippocampal function and GABA(A) receptor pathways, highlighting the critical role of GABAergic neurosteroids in brain development.
    Discuss this study in the Community →