Novel Modulatory Effects of Neurosteroids and Benzodiazepines on Excitatory and Inhibitory Neurons Excitability: A Multi-Electrode Array Recording Study

    January 2012 in “ Frontiers in Neural Circuits ”
    Giulia Puia, Francesca Gullo, Elena Dossi … Enzo Wanke
    Studysummary This study found that neurosteroids and benzodiazepines decrease network excitability in neuronal cultures, with specific long-term depressive effects on inhibitory neurons.
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    Research cited in this study 5

    1. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors Journal of Neuroscience · 2011
    2. Role of Neurosteroids in the Anticonvulsant Activity of Midazolam British Journal of Pharmacology · 2011
    3. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    4. Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007
    5. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002