Effects of Gonadal Drugs for Brain Neuroprotection in an Animal Model of Parkinson's Disease

This study explored the neuroprotective effects of dutasteride and finasteride in a mouse model of Parkinson's disease (PD) induced by MPTP. It was found that dutasteride, but not finasteride, exhibited neuroprotective activity on dopamine neurotransmission and had anti-inflammatory properties in the brain. The study suggested that dutasteride could be a promising therapeutic drug for neuroprotection in the early stages of PD. Additionally, previous findings indicated that progesterone could aid in the recovery of dopaminergic neurons when administered early after injury. The research highlighted the potential for gender-specific treatment options, such as using dutasteride for men and progesterone-based therapies for both sexes, but emphasized the need for further studies to optimize these therapies for safe, personalized treatment.