Effects of Gonadal Drugs for Brain Neuroprotection in an Animal Model of Parkinson's Disease

January 2017 in “ Corpus Université Laval (Université Laval) ”

Ahmed Nadhir Litim

dutasteride 5α-reductase finasteride progestérone dopaminergic neurons neuroprotection Avodart Propecia progesterone

Studysummary This study found that dutasteride may offer neuroprotective effects on dopaminergic neurons in an animal model of early-stage Parkinson's disease, suggesting potential therapeutic use.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Read the full study on hdl.handle.net →

Discuss this study in the Community →

Similar research 5

Effect of 5-Alpha Reductase Inhibitors in Animal Models of Parkinson's Disease Frontiers in Neuroendocrinology · 2024
Effect of the 5α-Reductase Enzyme Inhibitor Dutasteride in the Brain of Intact and Parkinsonian Mice Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology · 2017
Neuroactive Gonadal Drugs for Neuroprotection in Male and Female Models of Parkinson's Disease Neuroscience & Biobehavioral Reviews · 2015
Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson's Disease Models Frontiers in Pharmacology · 2022
The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease Neuropharmacology · 2015

Related Community Posts Join

6 / 1000+ results

community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Effect of dutasteride 0.5 mg/d in men who don't respond to finasteride (study)

in Research/Science 31 upvotes 1 year ago

Dutasteride improved hair density and thickness in men who didn't respond to finasteride, with some experiencing transient sexual dysfunction. Users discussed switching from finasteride to dutasteride, noting initial shedding but eventual hair improvement.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 2 years ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community Dutasteride and TRT study indicates improvement in aging male symptoms and no difference between placebo group and dutasteride group

in Finasteride/Dutasteride 45 upvotes 1 month ago

Dutasteride is recommended for men on testosterone replacement therapy (TRT) with DHT-sensitive hair, as it does not interfere with TRT's anabolic effects and may improve libido and aging male symptoms. Users report varying experiences with libido when switching from finasteride to dutasteride, with some noticing improvements and others experiencing fluctuations.