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This review explores the role of nutrition and probiotics in enhancing skin, hair, and nail health through gut microbiota, highlighting the potential of nutritional interventions for cosmetic benefits via the gut-skin axis.

Genetic factors affecting skin health and body weight may increase the risk of dermatophytosis.

In this study, researchers conducted a large genome-wide association meta-analysis and found 30 significant genetic loci linked to the risk of dermatophytosis, shedding light on the roles of keratin biology, skin barrier defects, immune dysfunction, and obesity in the disease.

This research review observed that topical hormone replacement therapy, particularly estradiol and estradiol-testosterone combinations, significantly increased Type I and III collagen synthesis in the skin of postmenopausal women, suggesting benefits against collagen loss-related skin aging effects such as reduced elasticity and increased dryness.

This study found that MAP-2 is intensely expressed in the companion layer of the hair follicle, suggesting its potential importance to follicle integrity and possible involvement in some types of alopecia.

This review discusses the integration of ultrasound in dermatology for improved lesion visualization and diagnosis, highlighting recent technological advancements like handheld devices and high-frequency probes, and reports no clinical results.

Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.

This retrospective study in Morocco confirms that Stevens-Johnson and Lyell syndromes lead to severe ocular and unsightly mucocutaneous sequelae, significantly affecting patients' social and professional integration.

In this study, researchers identified two distinct homozygous mutations in the KRT85 gene among consanguineous Pakistani families with pure hair and nail ectodermal dysplasia, highlighting variations in severity and potential impacts on the K85 protein function.

The document concludes that understanding nail anatomy is key for diagnosing nail diseases, early signs of nail melanoma may allow for less aggressive treatment, and specific genetic mutations are important in thyroid cancer prognosis and treatment.

This study found that activating BMP signaling in rodent and primate models significantly promotes nail and digit regeneration after amputation by enhancing the role of specific nail stem cells, though extreme proximal amputation only permitted partial regeneration without bone reconstruction.

This review discusses how emerging technologies in dermatology are enhancing the ability to diagnose and treat hair and nail disorders more accurately and effectively, highlighting advancements in both diagnostic techniques and therapeutic methods such as AI-driven technologies that personalize patient care and improve outcomes.

This chapter reviews disorders caused by mutations in epithelial keratins, highlighting a range of skin-related manifestations and the evolving role of molecular genetics in diagnosis, but reports no new clinical findings.

This study reveals that transglutaminase activity is widespread in integumentary structures of mammals and birds, suggesting it plays a significant role in the cornification of hard skin appendages like nails and feathers.

Non-scarring hair loss can be diagnosed with two 4mm punch biopsies, one cut vertically and the other transversely.

This study found that skin disorders are prevalent among elderly individuals and are often associated with underlying systemic diseases.

This review discusses the expanding applications of dermoscopy in dermatological diagnosis beyond its initial use for detecting dysplastic nevi and reports no new clinical results.

This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.

In this study using ex vivo porcine ear skin, researchers found that standard nail varnish applied gently creates effective follicular closures, preventing penetration of certain substances like fluorescein sodium salt and caffeine into hair follicles, whereas solvent-free varnish and rapid application techniques were less effective.

This review discusses how dysfunction in keratinocyte adhesion affects skin integrity and conditions like alopecia and keratoderma, highlighting the roles of intercellular junctions, and reports no new clinical results.

This study examined current literature and recommendations for preventing and treating skin lesions induced by chemotherapy, highlighting common dermatological issues such as discoloration, pruritus, and alopecia, and noting that specific treatments can alleviate these problems to improve patients' skin integrity, self-esteem, and quality of life.

This study highlights the potential benefits of combining dermoscopy with natural oil blends to improve the treatment of skin disorders and enhance patient compliance, but it emphasizes the need for further large-scale research to optimize these approaches in dermatology.

This study observed that transgenic mice expressing keratin K10 under bovine K6beta control developed severe oral abnormalities, suggesting keratin composition changes can affect the physiology of epithelial cells, especially in the oral mucosa.

This review highlights the significant impact of cutaneous and oral mucosal adverse events on patients undergoing breast cancer treatment, emphasizing the need for early detection and comprehensive management to maintain treatment adherence and enhance patient care.

This study analyzed the cornified envelope of epidermal proteins, finding keratins dominate, which may help explain the minimal impact of deleting genes for single envelope components in congenital ichthyosis.

This review discusses recent advances in the genetic understanding of inherited hair and nail disorders and reports no new clinical results.

This case report describes a father with HOXC13-associated pure hair-nail ectodermal dysplasia, presenting with severe nail dystrophy affecting all digits and notable hypotrichosis or complete alopecia.

In this randomized, placebo-controlled study, Titagen® was found to improve skin, hair, and nail health in adults consuming 5g daily, and reduce pain and improve quality of life for osteoarthritis patients taking 10g daily, without related adverse events.

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

This study found that protective measures against COVID-19, such as prolonged mask-wearing and frequent hand washing, were associated with skin issues, hair loss, and nail brittleness among participants in Iraq.