July 2023 in “International Journal of Molecular Sciences” This study found that N,N-dimethylglycine sodium salt promoted proliferation and migration of cultured human epidermal keratinocytes and had anti-inflammatory and antioxidant effects in vitro.
January 2023 in “Toxicological Research”
April 2021 in “Research Square (Research Square)” This case report describes significant improvements in both trichotillomania and bulimia symptoms with N-acetylcysteine treatment, suggesting a potential shared pathophysiological mechanism between the disorders.
February 2019 in “International Journal of Dermatology and Clinical Research” In this study, Nε-(carboxymethyl) lysine was found to weaken hair follicle morphogenesis and inhibit essential cell activities in a model simulating accumulated glycation.
This study found that ethanolic extract and fractions of Ceiba leaf tonic may enhance rabbit hair growth similarly to 2% minoxidil.
January 2019 in “Proceedings for Annual Meeting of The Japanese Pharmacological Society” In this study, injecting Nε-(carboxymethyl) lysine into skin tissue weakened hair shaft and follicle formation, likely by inhibiting cell proliferation and migration needed for hair follicle morphogenesis.
May 2018 in “International journal of clinical obstetrics and gynaecology” This study found that N-acetyl cysteine and metformin had equal effects on clinical outcomes in anovulatory infertile women with PCOS, but NAC was better tolerated with fewer side effects.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that N-acetyl-GED may protect and partially rescue human hair follicles from experimentally-induced epithelial-mesenchymal transition ex vivo, suggesting its potential in treating scarring alopecias like lichen planopilaris.
November 2016 in “The Molecular Biology Society of Japan” October 2006 in “Clinical Cancer Research” This study found that doxorubicin-induced oxidative stress downregulates FLIPs and phosphorylates EF2, sensitizing prostate cancer cells to TRAIL; antioxidants may reduce doxorubicin's effectiveness, warranting further investigation.
January 2005 in “Enlighten: Publications (The University of Glasgow)” In this transgenic mouse study, preliminary findings suggest that overt melanocyte hyperplasia may require prior keratinocyte hyperplasia, indicating a potential role for keratinocyte mutation in early melanoma development.
October 2021 in “QJM: An International Journal of Medicine” This study found that N-acetyl-cysteine alone or combined with minoxidil improved hair parameters in men with early-onset androgenetic alopecia, with tolerable side effects.
11 citations
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June 2016 in “European Journal of Medicinal Chemistry” This study found that two synthesized androst-4-ene-3-one derivatives, 6f and 6g, exhibited stronger anti-proliferative effects than common drugs on prostate cancer cell lines, with low toxicity to rat cells.
5 citations
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February 1998 in “Polymer” Human hair keratin has a 40% α-helix structure that changes to a random coil in 8 M urea.
4 citations
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December 2014 in “European Journal of Chemistry” This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.
1 citations
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August 2022 in “Frontiers in Physiology” This study suggests that finasteride may help alleviate high-fat diet-induced kidney damage in mice by reducing TMAO synthesis and regulating gut microbiota.
January 2025 in “Nanoscale” This study reports that a new boron/nitrogen-doped carbon nano-onion-based delivery system for doxorubicin enhanced its uptake and anticancer effects in specific cancer cell types, while reducing cardiotoxicity in human heart cells.
November 2021 in “Pharmaceutical Sciences” This study found that the compound androstane-17-carboxamide 6 may serve as a lead for new drugs to treat BPH and prostate cancer by reducing the weight of androgen-dependent glands.
26 citations
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July 2007 in “Biochemical Pharmacology” This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.
18 citations
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October 2017 in “Drug Design Development and Therapy” The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.
18 citations
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September 2003 in “International Journal of Cancer” This study found that Epstein-Barr virus infection upregulated a truncated variant of human basic hair keratin 1 (hHb1-ΔN) in gastric carcinoma cell lines, suggesting a possible link to carcinoma differentiation.
17 citations
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October 2005 in “Journal of Biological Chemistry” This study found that Hirosaki hairless rats experience transient activation of STAT5A in the mammary glands during early lactation, involving O-GlcNAc modification rather than Tyr-phosphorylation.
16 citations
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September 2017 in “PLoS ONE” This study hypothesizes that a mummified 19th Century girl in San Francisco died of severe undernourishment potentially due to a bacterial-borne disease, highlighting historical health challenges mitigated by modern sanitation and medicine.
14 citations
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February 2014 in “Nutrition in Clinical Practice” This A.S.P.E.N. document offers guidance for managing parenteral nutrition shortages, emphasizing alternative routes and careful allocation to prevent deficiencies.
10 citations
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August 1998 in “Journal of Investigative Dermatology” This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.
7 citations
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March 2013 in “Tetrahedron Letters” This study reports a new one-pot method for synthesizing chromeno-pyrimidine-N-oxides with high yield from 4-chloro-3-formylcoumarin and aromatic carboximide oximes, confirmed by X-ray analysis.
2 citations
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January 2012 in “Hair therapy & transplantation” This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.
1 citations
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September 2024 in “Benha Journal of Applied Sciences” This review provides an overview of androgenetic alopecia, detailing its causes, diagnostic methods, and current treatments, noting that combination therapies show promise but newer options like cell-based treatments require more research.
December 2024 in “Benha Journal of Applied Sciences” This study reports that combination therapies, including surgical and various medical treatments, show promise for managing androgenetic alopecia, though further research is necessary to confirm the safety and effectiveness of emerging therapies.
This article describes the "naked" mouse mutation, which results in hair loss and is linked to chromosome 15, noting similarities and differences with human ectodermal dysplasia, but provides no new experimental findings.