TLDR The naked mutation in mice causes hair loss and helps identify keratin genes.
The naked (N) mutation in mice, discovered at Latvia University, resulted in homozygous mice lacking a hair coat and heterozygous mice losing their initial hair coat between 10 to 14 days of age. This mutation was linked to the velvet coat (Ve) mutation on Chromosome 15, aiding in identifying mouse keratin genes. Although the naked mutation resembled the human condition hydrotic ectodermal dysplasia, the amino acid changes in hair differed between species. Similar hereditary alopecia, a form of ectodermal dysplasia, was observed in certain dog breeds.
21 citations
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April 1982 in “Genetics Research” Mice with the naked gene have missing or abnormal hair cells.
52 citations
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October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
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August 2020 The Shaven mutation in mice affects hair growth and causes a greasy coat due to abnormal lipid content.
January 2024 in “International journal of molecular sciences” Hoxc13 gene affects wool length in Gansu alpine fine-wool sheep.
3 citations
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January 2010 in “Elsevier eBooks” The document describes various skin conditions, their features, and treatments but lacks detailed study size information.
