research Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines
New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
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research Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives
A new method efficiently modifies alkenes to create useful medicinal compounds.
research An Efficient Synthesis of Dutasteride: Utilizing Benzoyl Group as Novel Lactamic Protecting Group
Researchers created a new, efficient way to make Dutasteride, a hair loss and prostate drug, with high purity using a benzoyl group.
research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen
In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.
research Pantolactams as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production
Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.
research Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice
MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.
![Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1](/images/research/c687900f-ea40-4de1-8f0b-a5b818951b1c/small/15452.jpg)
research Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1
Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
research Cyclohex-1-Ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase
Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.
![Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase](/images/research/d91300a7-4d66-4d2c-90ac-293b0dbc5ff5/small/21048.jpg)
research Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase
Compound 15a was effective in inhibiting 5α-reductase.
research New Fluorogenic Probes for Neutral and Alkaline Ceramidases
New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.
![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/research/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
research Development of Novel Wound Dressing Based on Elastin-Like Recombinamers for Skin Regeneration
Elastin-like recombinamers show promise for better wound healing and skin regeneration.
research Surface Modification and Endothelialization of Biomaterials as Potential Scaffolds for Vascular Tissue Engineering Applications
Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.
research Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents
Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
research RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism
RU 58841 may treat acne, hair loss, and excessive hair growth.
research Design and Synthesis of Novel Androgen Receptor Antagonists with Sterically Bulky Icosahedral Carboranes
New compounds with carborane showed anti-androgen effects similar to flutamide.
research Recent Advances in Oxasteroids Chemistry
New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
research Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands
Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.
research Enzymatic Synthesis of Alpha-Glucosyl-Baicalin Through Transglucosylation via Cyclodextrin Glucanotransferase in Water
Enzymatic synthesis improved the water solubility of the flavonoid baicalin, which may help treat hair loss conditions.
research Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production
Plant sterols have health benefits like lowering cholesterol, but more research is needed to understand their effects and improve their extraction and sustainability.
research Release Systems Based on Self-Assembling RADA16-I Hydrogels With a Signal Sequence Which Improves Wound Healing Processes
Self-assembling RADA16-I hydrogels with bioactive peptides significantly improve wound healing.
research In Vitro Hair Growth-Promoting Effect of Lgr5-Binding Octapeptide in Human Primary Hair Cells
A synthetic octapeptide may help promote hair growth and counteract hair loss.
research Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines
The document concludes that specific methods for making diazine-based drugs can lead to high yields and are important for creating effective treatments for various diseases.
research Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures
A blood pressure drug, diltiazem, may also help treat influenza.
research FASCE: The Benefit of Spironolactone for Treating Acne in Women - Study Protocol for a Randomized Double-Blind Trial
The trial aims to test if spironolactone is an effective acne treatment for women without the side effects of current treatments.
research Complications in Aesthetic Surgery
Esthetic surgery complications can include infections, nerve injury, and more; proper evaluation and technique help prevent them.
research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome
Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
research Highlights
Melatonin may help with nerve pain, a hepatitis C drug is effective but has side effects, a treatment for mouth sores works but can cause blood issues, ear reconstruction with an implant is safe, HIV transmission from mother to child in Taiwan is now 0% with treatment, certain blood problems are more common in people with a tongue condition, a gene and being overweight are linked to hair loss in some women, a new technique could reduce radiation for lung nodule patients, a hepatitis treatment may lower cancer recurrence after a procedure, and adding extra screening improves tuberculosis detection in patients with lung infections.
research K ATP Channels and Cardiovascular Disease
K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.