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Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Human skin can make serotonin and melatonin.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

Key genes are crucial for Drosophila wing development and could be insecticide targets.

Melatonin affects mouse skin and may regulate skin functions.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Putting α-methylspermidine on mouse skin can start hair growth.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Melatonin protects skin against UV damage by regulating various cellular processes.

The Polish Dermatological Society recommends personalized treatment for cutaneous lupus, including lifestyle changes, medications, and monitoring, with specific drugs for severe cases.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Melatonin may reduce skin damage caused by X-rays in rats.

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

The article concludes that advancements in hair cosmetics require dermatologists to stay informed about products and their potential risks, including allergies and higher risks for hairdressers.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.