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    Glossary Multipotent Stem Cells

    can develop into multiple, but limited, cell types

    Multipotent stem cells are a type of stem cell that can develop into multiple, but limited, cell types within a particular tissue or organ. For example, hematopoietic stem cells in the bone marrow can differentiate into various types of blood cells, but not into cells of other tissues like neurons or muscle cells. These cells are crucial for tissue repair and regeneration, making them a significant focus in medical research and therapies.

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    1. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    2. Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing Stem Cell Research & Therapy · 2020 · 4 citations
    3. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001 · 949 citations
    4. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes & Development · 2001 · 555 citations
    5. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    6. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    7. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia Journal of Dermatological Science · 2012 · 59 citations
    8. Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures PLoS ONE · 2012 · 58 citations
    9. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors International Journal of Molecular Medicine · 2013 · 56 citations
    10. Multipotent nestin‐expressing hair follicle stem cells The Journal of Dermatology · 2009 · 37 citations
    11. Fresh Umbilical Cord Blood—A Source of Multipotent Stem Cells, Collection, Banking, Cryopreservation, and Ethical Concerns Life · 2023
    12. Faculty Opinions recommendation of Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    13. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function Cell Cycle · 2008 · 144 citations
    14. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014 · 10 citations
    15. Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells Stem Cell Research · 2011 · 73 citations
    16. Multipotent nestin-expressing stem cells capable of forming neurons are located in the upper, middle and lower part of the vibrissa hair follicle Cell Cycle · 2012 · 47 citations
    17. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons Proceedings of the National Academy of Sciences · 2005 · 419 citations
    18. Long-term renewal of hair follicles from clonogenic multipotent stem cells Proceedings of the National Academy of Sciences of the United States of America · 2005 · 291 citations
    19. Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles In vitro cellular & developmental biology. Animal · 2008 · 34 citations
    20. Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro PloS one · 2013 · 33 citations
    21. Isolation of Multipotent Nestin-Expressing Stem Cells Derived from the Epidermis of Elderly Humans and TAT-VHL Peptide-Mediated Neuronal Differentiation of These Cells International Journal of Molecular Sciences · 2013 · 12 citations
    22. The multipotency of adult vibrissa follicle stem cells Differentiation · 2009 · 8 citations
    23. Thymic epithelial cells : relatives of multipotent stem cells of the skin Infoscience (Ecole Polytechnique Fédérale de Lausanne) · 2008
    24. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012 · 65 citations
    25. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    26. The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome by Asymmetrical Chromosome Segregation Stem Cells · 2008 · 61 citations
    27. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells Development · 2013 · 74 citations
    28. The Hair Follicle Stem Cell as the Paradigm Multipotent Adult Stem Cell Springer eBooks · 2008 · 1 citations
    29. The Autologous Hair Follicle and Its Secretome: A Multipotent Source for Cell-Based and Cell-Free Regenerative Therapies International Journal of Molecular Sciences · 2026
    30. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations