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GlossaryMononuclear Cells

white blood cells with a single round nucleus

Mononuclear cells, also known as mononuclear leukocytes or MNCs, are a type of white blood cell characterized by having a single round nucleus. These cells include lymphocytes and monocytes, which play crucial roles in the immune system by fighting infections and aiding in immune responses.

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Hallmark Evidence of Lipopolysaccharide Tolerance in Obese Women with Polycystic Ovary Syndrome: LPS-Induced NFkB Suppression in Mononuclear Cells Linked to Hyperandrogenism

research Hallmark Evidence of Lipopolysaccharide Tolerance in Obese Women with Polycystic Ovary Syndrome: LPS-Induced NFkB Suppression in Mononuclear Cells Linked to Hyperandrogenism

September 2018 in “Fertility and Sterility”

High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.

Impaired Responses of Peripheral Blood Mononuclear Cells to T-Cell Stimulants in Alopecia Areata Patients with a Poor Response to Topical Immunotherapy

research Impaired Responses of Peripheral Blood Mononuclear Cells to T-Cell Stimulants in Alopecia Areata Patients with a Poor Response to Topical Immunotherapy

4 citations, July 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

Poor response to topical immunotherapy in alopecia areata patients is linked to impaired cell responses.

research Subset Analysis of NKG2D+ Cells in Peripheral Blood Mononuclear Cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study suggests that a specific type of immune cell, memory-like NK cells, may increase during active hair loss in Alopecia areata.

Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

1 citations, October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

research Availability of mRNA from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

November 2022 in “Journal of Investigative Dermatology”

Scientists developed a new way to study mutations in a skin condition using blood cells, which may help diagnose and treat the disease.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations, September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research Altered Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

12 citations, March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

research To Identify the Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Alopecia Areata

November 2023

Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.

research The Role of Platelet-Rich Plasma in the Prevention of Chemotherapy-Induced Alopecia

2 citations, November 2019 in “Skin appendage disorders”

Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.

research Effect of Cellular Blood Components on Chemotherapy-Induced Alopecia

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mononuclear cells may protect against certain chemotherapy-induced hair loss.

research Role of Cytotoxic T Cells in Chronic Alopecia Areata

127 citations, January 2000 in “Journal of Investigative Dermatology”

Cytotoxic T cells cause hair loss in chronic alopecia areata.

research Increase in CD8+ Effector Memory Cells Re-Expressing CD45RA Reflects Disease Activity and Enables Early Prediction of Therapeutic Outcome in Rapidly Progressive Alopecia Areata

April 2023 in “Journal of Investigative Dermatology”

Increased TEMRA cells can predict treatment outcomes in rapidly progressive alopecia areata.

research iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata

27 citations, April 2018 in “Journal of autoimmunity”

iNKT cells can help prevent and treat alopecia areata by promoting hair regrowth.

A Cellular Study of Inflammatory Responses in Women with Polycystic Ovary Syndrome: An In Vitro Model of Anti-Breast Tumor Response - A Case Control Study

research A Cellular Study of Inflammatory Responses in Women with Polycystic Ovary Syndrome: An In Vitro Model of Anti-Breast Tumor Response - A Case Control Study

April 2020 in “Research Square (Research Square)”

Women with PCOS may have a reduced ability to fight breast tumor cells over time.

research Synthesis of Minoxidil Conjugates and Their Evaluation as HL-60 Differentiation Agents

6 citations, January 2016 in “Bioorganic & Medicinal Chemistry Letters”

Some minoxidil combinations can help differentiate leukemia cells without harming other cells.

research Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

55 citations, April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

research Alopecia in Laboratory Animals Induced by a Polyampholyte, Polyethylene Alanine

2 citations, September 1980 in “Experientia”

Polyethylene alanine caused hair loss in young lab animals but not in adults, with hair regrowth occurring within 20 days.

research Pathogenesis of Alopecia Areata in C3H/HeJ Mice and DEBR Rats

January 2006

Alopecia areata is an autoimmune disease that targets hair follicles.

research Characterization of Novel TMEM173 Mutation with Additive IFIH1 Risk Allele

1 citations, August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

research Disturbance of the Circadian System in Shift Work and Its Health Impact

103 citations, December 2021 in “Journal of biological rhythms”

Shift work disrupts the body's natural clock, leading to health problems.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations, August 2016 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles

47 citations, December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Alopecia Areata Incognita: A Case Report

19 citations, January 2011 in “Clinics”

A young woman with a rare hair loss condition improved with steroid and biotin treatment.