TLDR Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.
The study explored the efficacy of platelet-rich plasma (PRP) and mononuclear cells (MC) in preventing chemotherapy-induced alopecia (CIA) in a young rat model, involving 18 rats divided into three groups. Each group was subjected to different chemotherapeutic agents (Ara-C, VP-16, and Cytoxan) and received PRP, MC, or a control PBS treatment. The results indicated that PRP failed to protect against CIA for all chemotherapies tested, while MC provided protection only against alopecia caused by Ara-C, potentially due to increased IL-1 expression. The study concluded that PRP is not effective in preventing CIA, and MC's protective effect is limited to Ara-C treatment and may be IL-1 mediated.
25 citations
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July 2017 in “Journal of Stomatology, Oral and Maxillofacial Surgery” PRP injections help regrow hair, reduce hair loss, and increase hair thickness, but effects decrease without ongoing treatment.
3 citations
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May 2017 in “Heliyon” Wound healing can help prevent hair loss from chemotherapy in young rats by increasing interleukin-1β signaling.
218 citations
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January 2013 in “The Lancet Oncology” Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.
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January 1996 in “International Journal of Cancer” AS101 reduces hair loss from chemotherapy.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Mononuclear cells may protect against certain chemotherapy-induced hair loss.
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March 2019 in “Frontiers in Cellular Neuroscience” The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.
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September 2019 in “Clinical, Cosmetic and Investigational Dermatology” Light therapy can stimulate hair growth and is more effective when started early, but more research is needed on its long-term effects and optimal use.
August 2024 in “Stem Cell Research & Therapy” New regenerative therapies show promise for treating hair loss.
Advancements in diagnostics, treatments, and technology have improved hair loss detection and restoration, with some types being reversible.
