TLDR Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.
The study explored the efficacy of platelet-rich plasma (PRP) and mononuclear cells (MC) in preventing chemotherapy-induced alopecia (CIA) in a young rat model, involving 18 rats divided into three groups. Each group was subjected to different chemotherapeutic agents (Ara-C, VP-16, and Cytoxan) and received PRP, MC, or a control PBS treatment. The results indicated that PRP failed to protect against CIA for all chemotherapies tested, while MC provided protection only against alopecia caused by Ara-C, potentially due to increased IL-1 expression. The study concluded that PRP is not effective in preventing CIA, and MC's protective effect is limited to Ara-C treatment and may be IL-1 mediated.
25 citations,
July 2017 in “Journal of Stomatology, Oral and Maxillofacial Surgery” PRP injections help regrow hair, reduce hair loss, and increase hair thickness, but effects decrease without ongoing treatment.
3 citations,
May 2017 in “Heliyon” Wound healing can help prevent hair loss from chemotherapy in young rats by increasing interleukin-1β signaling.
218 citations,
January 2013 in “The Lancet Oncology” Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Mononuclear cells may protect against certain chemotherapy-induced hair loss.
142 citations,
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34 citations,
September 2019 in “Clinical, Cosmetic and Investigational Dermatology” Light therapy can stimulate hair growth and is more effective when started early, but more research is needed on its long-term effects and optimal use.
August 2024 in “Stem Cell Research & Therapy” New regenerative therapies show promise for treating hair loss.
10 citations,
October 2015 in “Medicina Clínica (english Edition)” Recombinant human epidermal growth factor is versatile, effective, and safe for long-term skin and mucosal treatments.
