The Role of Platelet-Rich Plasma in the Prevention of Chemotherapy-Induced Alopecia
November 2019
in “
Skin appendage disorders
”
TLDR Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.
The study explored the efficacy of platelet-rich plasma (PRP) and mononuclear cells (MC) in preventing chemotherapy-induced alopecia (CIA) in a young rat model, involving 18 rats divided into three groups. Each group was subjected to different chemotherapeutic agents (Ara-C, VP-16, and Cytoxan) and received PRP, MC, or a control PBS treatment. The results indicated that PRP failed to protect against CIA for all chemotherapies tested, while MC provided protection only against alopecia caused by Ara-C, potentially due to increased IL-1 expression. The study concluded that PRP is not effective in preventing CIA, and MC's protective effect is limited to Ara-C treatment and may be IL-1 mediated.
