August 2025 in “Frontiers in Pharmacology” This study identified three Ayurvedic compounds that may serve as potential treatments against the macrolide-resistant enzyme murE of *Tropheryma whipplei*, addressing challenges in treating Whipple disease.
101 citations
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September 2006 in “Journal of Biological Chemistry” This research quantified the fidelity of human mitochondrial DNA polymerase and found it averages 1 error in 440,000 nucleotides, impacting its function related to disease and mitochondrial health.
20 citations
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May 2013 in “International Journal of Molecular Medicine” This study identified a novel missense MAFB variant in a family with some unaffected members, suggesting incomplete penetrance and the potential influence of modifier genes, epigenetic mechanisms, or environmental factors on MCTO phenotype.
17 citations
,
September 1953 in “Journal of Cell Science” This study found that the tetrazolium salt INT is the most effective for revealing dehydrogenase activity and certain histological structures in sheep and other mammals' skin.
3 citations
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February 2025 in “Metabolites” In this study, researchers identified specific Se6OMT enzymes in *S. epigaea* involved in the cepharanthine biosynthetic pathway, providing insights into their substrate promiscuity and essential genetic components for metabolic engineering and synthetic biology applications of cepharanthine production.
November 2024 in “European Journal of Pharmacology” In this study, MitoQ was found to enhance hair growth and reverse DHT-induced hair loss in a mouse model of androgenetic alopecia by mediating the WNT/β-catenin pathway and increasing CYP19A1 expression, suggesting potential as a therapeutic intervention.
September 2022 in “Medical Mycology” This study found that three protocols for generating Titan cells in vitro from Candida neoformans vary in their kinetics and transcriptomic profiles, pointing to differences which could impact further research.
28 citations
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January 2004 in “British Journal of Pharmacology” This study found that minoxidil provides cardioprotective effects in guinea-pig heart cells through selective activation of mitochondrial ATP-sensitive potassium channels.
13 citations
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October 2017 in “Bioorganic & Medicinal Chemistry” This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
December 2025 in “Mycoses” In this study involving a murine skin infection model, researchers found that the Trichophyton mentagrophytes strain TIMM 2789, specific to rodents, induced typical symptoms of superficial dermatophytosis, while revealing that the fungal gene SUB6 is not essential for virulence.
4 citations
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December 2024 in “International Journal of Molecular Sciences” This study found that extracts from Hom Thong banana peels, rich in phenolic compounds, may inhibit melanin production in human and mouse melanoma cells, showing potential as anti-melanogenic agents comparable to standard treatments like arbutin and kojic acid.
9 citations
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July 2020 in “Biomedicine & Pharmacotherapy” This study found that Pep-1-mediated mitochondrial transplantation was as effective as PRP therapy in restoring hair loss related to aging in mice, with distinct improvements in hair and skin-related measures.
12 citations
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June 2022 in “International Journal of Molecular Sciences” In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.
161 citations
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August 2013 in “Journal of experimental botany” This study found that specific ATP-competitive TOR inhibitors (asTORis) decrease root growth in Arabidopsis thaliana in a dose-dependent manner, similar to their effects on mammalian cells.
83 citations
,
May 2022 in “Journal of Advanced Research” This study suggests that enhancing glycolysis in MSCs may improve their immune functions and therapeutic potential, although more evidence is needed to understand the direct metabolic mechanisms involved.
33 citations
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March 2018 in “Trends in cell biology” This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.
26 citations
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October 2011 in “International Journal of Biological Macromolecules” This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.
95 citations
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August 2013 in “Journal of Investigative Dermatology” HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.
This study reports that melatonin influenced HaCaT cell proliferation, with high concentrations reducing DNA synthesis and low concentrations enhancing it after 24 hours.
76 citations
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June 2015 in “Journal of biomedical science” This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.
36 citations
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January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the connection between PI3K-AKT-mTOR pathway mutations and heritable skin diseases characterized by tissue overgrowth, but it reports no new clinical results.
4 citations
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October 2013 in “Springer eBooks” This chapter reviews existing knowledge about melatonin's MT₁ and MT₂ receptors in human tissues, discussing their established and potential functions, but reports no new clinical findings.
2 citations
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May 2021 in “Neuropathology & applied neurobiology/Neuropathology and applied neurobiology” This correspondence reports the case of a young woman with severe lipid storage myopathy due to a rare mutation, who showed significant temporary improvement with plasmapheresis and immunoglobulin treatment before stabilizing with riboflavin and coenzyme Q10 supplementation, challenging the initial assumption of an immune-mediated condition.
January 2024 in “Research Portal Denmark” This thesis reveals that tenuazonic acid inhibits plant plasma membrane H+-ATPase, suggesting its potential as a herbicide due to its impact on root elongation and cell viability in Arabidopsis thaliana.
29 citations
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January 2020 in “BioMed Research International” This study found that sinapic acid promotes the browning of 3T3-L1 adipocytes and may offer therapeutic potential for obesity by influencing mitochondrial biogenesis through the p38 MAPK/CREB signaling pathway.
April 2015 in “Journal of Nutritional Therapeutics” This study found that a more liberal intake of restricted amino acids in patients with methylmalonic acidemia resulted in improved growth and fewer illness episodes.
January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the ethyl acetate extract of Semecarpus anacardium leaves demonstrated cytotoxicity against MCF-7 cancer cells and induced apoptosis, suggesting potential as a cancer treatment with fewer side effects.
August 2023 in “Frontiers in Endocrinology” This study identified novel mitochondrial DNA variations in PCOS patients from Pakistan, which may serve as genetic predisposition markers, highlighting especially the potential pathogenicity of frameshift mutations in the MT-ND2 gene.
June 2026 in “International Journal of Molecular Sciences” This review synthesizes current evidence on the Warburg effect in anaplastic thyroid carcinoma and discusses potential therapeutic targets, but reports no new clinical results.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review compiles information on Musa paradisiaca, highlighting its morphological features, traditional medicinal uses, chemical composition, and pharmacological activities, including anti-diabetic and anti-ulcer properties among others.