This study optimized a murine infection model using the Trichophyton mentagrophytes TIMM 2789 strain, specific to rodents, to study dermatophytosis pathogenesis. The model successfully mimicked natural infections, showing symptoms like hair follicle invasion. Host responses involved Th1, Th2, and Th17 cytokines, while the fungal SIDC gene highlighted the role of iron acquisition. Although SUB6 was not necessary for virulence, SUB5 overexpression suggested a compensatory mechanism. The study emphasizes the importance of selecting appropriate dermatophyte strains for experimental models.
21 citations
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February 2009 in “Journal of the American Academy of Dermatology” Some cases of tinea capitis, a fungal scalp infection, can look like scarring hair loss due to the body's immune response and the fungus itself.
72 citations
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June 2013 in “Journal of feline medicine and surgery” The document says to treat cat fungal infections with medicine and clean the environment, noting that cats without symptoms can still spread it to humans.
December 2024 in “Indonesian Journal of Tropical and Infectious Disease” Tinea corporis and tinea cruris are the most common skin infections in Surabaya, mainly affecting adult women.
May 2024 in “Journal of Fungi” Tinea capitis in adults, especially postmenopausal Black women, needs prompt treatment with oral antifungals to avoid scarring.
2 citations
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January 2006 in “Indian Journal of Veterinary Pathology” Trichophyton mentagrophytes causes skin issues and nutrient deficiencies in young sheep, especially in winter.
