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research Optimization of a Murine Infection Model With Trichophyton Mentagrophytes for Studying the Pathogenesis of Dermatophytosis

December 2025 in “Mycoses”

This study optimized a murine infection model using the Trichophyton mentagrophytes TIMM 2789 strain, specific to rodents, to study dermatophytosis pathogenesis. The model successfully mimicked natural infections, showing symptoms like hair follicle invasion. Host responses involved Th1, Th2, and Th17 cytokines, while the fungal SIDC gene highlighted the role of iron acquisition. Although SUB6 was not necessary for virulence, SUB5 overexpression suggested a compensatory mechanism. The study emphasizes the importance of selecting appropriate dermatophyte strains for experimental models.

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

30 citations , July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

A Novel Nonsense Mutation in the STS Gene in a Pakistani Family with X-Linked Recessive Ichthyosis: Including a Very Rare Case of Two Homozygous Female Patients

research A Novel Nonsense Mutation in the STS Gene in a Pakistani Family with X-Linked Recessive Ichthyosis: Including a Very Rare Case of Two Homozygous Female Patients

6 citations , January 2020 in “BMC Medical Genetics”

A new mutation in the STS gene causes X-linked ichthyosis, even in rare female cases.

research The RpoS Gatekeeper in Borrelia Burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

91 citations , August 2019 in “Frontiers in Microbiology”

RpoS helps Borrelia burgdorferi survive in hosts and adapt to different environments.

Community Join

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community Pleasant surprise Eyebrow and eyelash gains

in Is this regrowth? 149 upvotes 2 months ago

The user experienced significant eyebrow and eyelash growth after starting a hair loss treatment routine that includes oral minoxidil, oral dutasteride, topical minoxidil, Nizoral shampoo, microneedling, and supplements. They also reported positive scalp hair gains and no significant side effects.

community Has anyone seen any benefit upgrading from fin to dut?

in Finasteride/Dutasteride 14 upvotes 1 year ago

Users discuss switching from finasteride to dutasteride for hair loss treatment. Some report better results with dutasteride, including hair regrowth and stabilization.

community Thank you guys! Before this sub I thought all hair-grow-back product are scam.

in Minoxidil 642 upvotes 9 months ago

A user shared their positive experience with hair regrowth using Finasteride and Minoxidil, noting increased confidence and no serious side effects except for increased body hair. Others in the conversation discussed varying results, potential side effects, and the possibility of switching to Dutasteride if effectiveness decreases.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 101 upvotes 1 year ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

community Posted this years ago but still getting questions!

in Progress Pictures 326 upvotes 1 year ago

The user successfully treated their hair loss using 1ml of minoxidil twice daily and dermarolling with a 1.5mm dermaroller once a week. They experienced noticeable results only after combining minoxidil with dermarolling, and they have not used finasteride.