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This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This review highlights the critical role of mitochondrial dysfunction in hair loss, particularly androgenetic alopecia, and explores potential therapies targeting mitochondrial pathways to improve hair health, underscoring the need for further research in this area.

This review synthesizes preclinical evidence suggesting that Centella asiatica may extend healthspan by modulating aging hallmarks, enhancing DNA repair, improving mitochondrial function, and reducing inflammation and oxidative stress, potentially paving the way for future gerotherapeutic strategies.

This study identified mefloquine as a potent inducer of lethal ER stress that effectively eliminated vemurafenib-resistant and sensitive melanoma cells, suggesting its potential for repurposing as a melanoma treatment.

In this review, researchers critically examine contemporary treatments for androgenetic alopecia, emphasizing advanced drug delivery systems, regenerative medicine, and emerging molecular targets, while identifying significant gaps that hinder translating these innovations into clinical practice.

Hair follicle stem cells and mitochondria are key for hair growth, and targeting their activity could lead to new hair loss treatments.

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.

This study found that targeting peroxisomal dysfunction with catalytic nanozymes enhanced hair follicle regeneration and outperformed minoxidil in promoting hair growth and maintaining efficacy in immunodeficient mice.

This study suggests that targeting mitophagy to regulate mitochondrial dysfunction and inhibit inflammasome activation could offer a novel therapeutic approach for alopecia areata.

The project aims to validate a nutritional intervention targeting the Redox–NO–Androgen Axis to restore mitochondrial, endothelial, and hormonal balance in male health disorders related to oxidative stress.

This study found that the Keyora Lycopene 23 in 1 formulation may improve various aspects of male endocrine and reproductive health by targeting oxidative stress, nitric oxide deficiency, and hormonal imbalance.

In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.

This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.

This paper proposes a novel theory that certain symptoms of Post-Finasteride Syndrome may be caused by an overgrowth of hydrogen sulphide-producing bacteria in the small intestine, which acts as a mitochondrial toxin, with implications for treatment targeting the gut microbiome.

This review synthesizes recent molecular and preclinical advances in alopecia areata and androgenetic alopecia, highlighting how interventions targeting specific intracellular signaling pathways and utilizing stem cell technologies can support precision regrowth and structural follicle reconstruction.

In this study, researchers found that mitochondrial complex I plays a crucial role in regulating innate immunity and bone remodeling, with Ndufs4 deletion causing systemic inflammation and osteopetrosis through various metabolic shifts and cellular mechanisms.

In this study, researchers found that depleting mtDNA in mice caused skin wrinkles and hair loss but restoring mitochondrial function reversed these effects, highlighting mtDNA's significant role in skin and hair health.

This article discusses the relationship between mitochondrial DNA damage and atherosclerosis, suggesting that mtDNA damage may increase plaque vulnerability independent of reactive oxygen species, but reports no new clinical results.

This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

This study found that early mitochondrial reprogramming, specifically through fatty acid oxidation fueling oxidative phosphorylation, is crucial for initiating differentiation in epidermal stem cells, highlighting a potential therapeutic target for differentiation defects in skin disorders.

This study suggests that MPZL3, a mitochondrially localized protein, may play an integral role in regulating hair follicle cycles, with potential therapeutic implications for hair growth disorders if findings translate to humans.

This review examines the role of androgens and androgen receptors in regulating glucose and lipid metabolism, focusing on their effects on mitochondrial content and function; it also discusses the sex-dimorphic influence of androgens and provides theoretical insights into their mechanisms.

This review explores the complex relationships between ferroptosis, anastasis, and chemoresistance in cancer therapy, highlighting the potential of combining ferroptosis with immunotherapy to overcome resistance and improve personalized cancer treatments.

This review discusses therapeutics for mitochondrial dysfunction and reports no new clinical findings.

This study suggests that Myelin Protein Zero-like 3 plays a crucial role in hair follicle cycling by regulating anagen and catagen phases, mediated through mitochondrial signaling mechanisms in both human and murine hair follicles.

In this study, MitoQ was found to enhance hair growth and reverse DHT-induced hair loss in a mouse model of androgenetic alopecia by mediating the WNT/β-catenin pathway and increasing CYP19A1 expression, suggesting potential as a therapeutic intervention.