24 citations
,
November 2013 in “Trends in pharmacological sciences” This article describes a potential novel approach to reduce chemotherapy-induced hair loss by enhancing the expression of specific transporters in hair follicles, but reports no clinical results.
24 citations
,
May 2010 in “Hautarzt” This review explores various hormone influences on hair growth and loss beyond androgens, noting that clinical hormone therapies for aging may impact hair due to associated hormone level reductions, but reports no new empirical results.
24 citations
,
January 2008 in “KARGER eBooks” This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.
24 citations
,
June 2021 in “Agronomy” This study found that biostimulant application in lettuce cultivation led to significant yield and phytochemical enhancements, with effects varying between green and red cultivars depending on the treatment method used.
23 citations
,
December 2020 in “Frontiers in Cell and Developmental Biology” This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.
23 citations
,
June 2012 in “PLOS ONE” This study found that KLF4 expression in mouse hair follicle stem cells is important for effective cutaneous wound healing, with its knockdown leading to reduced stem cell populations and delayed healing.
23 citations
,
January 2014 in “International Journal of Biological Sciences” This study found that African American men with prostate cancer have higher rates of somatic and germline androgen receptor mutations than Caucasian American men, which may contribute to ethnic differences in disease progression and outcomes.
22 citations
,
May 2021 in “Nature Communications” This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.
22 citations
,
August 2019 in “Environmental research” This study found that the Pseudomonas sp. T5-6-I strain significantly increased selenium accumulation and root hair density in Brassica oleracea, highlighting its potential for phytoremediation and biofortification.
22 citations
,
January 2018 in “Experimental Dermatology” This article reviews insights into the pathogenesis of primary cicatricial alopecias, such as lichen planopilaris, provided by emerging technologies, but it does not report new clinical results.
22 citations
,
December 2013 in “Molecular biology of the cell” This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.
22 citations
,
October 2012 in “Journal of Investigative Dermatology” This study found that C57BL/6 mice with a diet containing specific levels of vitamin A showed alterations in retinoid metabolism and increased frequency of cicatricial alopecias, suggesting dietary factors may play a role in this condition.
22 citations
,
June 2012 in “PLOS ONE” In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.
22 citations
,
August 2009 in “Evidence-based Complementary and Alternative Medicine” This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.
22 citations
,
March 2009 in “Journal of Natural Medicines” This study found that Erica multiflora extract promotes hair growth by enhancing dermal papilla cell activity and shifting hair follicles from the telogen to the anagen phase in both in vitro and in vivo models.
21 citations
,
April 2019 in “Endocrinology and Metabolism Clinics of North America” This review discusses skin diseases in transgender patients receiving gender-affirming hormone therapy and procedures, highlighting unique conditions and the underdiagnosis that affects their quality of life and mental health.
21 citations
,
March 2019 in “Critical Reviews in Clinical Laboratory Sciences” This review discusses the role of the androgen receptor in breast cancer diagnosis and treatment, and notes a lack of new research results on its therapeutic potential.
21 citations
,
March 2018 in “Experimental Dermatology” This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.
21 citations
,
December 2016 in “PLOS ONE” This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.
21 citations
,
April 2016 in “Journal of Dermatological Treatment” This paper discusses the potential relationship between finasteride's adverse effects and factors like hand preference and sexual orientation, suggesting these could influence risk in male androgenic alopecia treatment, but reports no new clinical results.
21 citations
,
October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
20 citations
,
October 2021 in “PLoS ONE” This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.
20 citations
,
June 2019 in “Experimental Dermatology” This study identified 14 genes affected by copy number variants that may contribute to alopecia areata, including four genes notably involved in autophagy and chromatin remodeling.
20 citations
,
September 2015 in “Journal of The European Academy of Dermatology and Venereology” This study found that 5% minoxidil topical foam was effective in stabilizing hair density and scalp coverage in men with moderate androgenetic alopecia over 104 weeks, with good safety and tolerability.
20 citations
,
August 2014 in “PloS one” This study found that MED1 deficiency in keratinocytes accelerates skin wound healing in young mice but delays healing in older mice, suggesting differential roles in epidermal regeneration with age.
20 citations
,
June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
20 citations
,
January 2013 in “Cell & Bioscience” This review discusses recent findings on the epigenetic regulation of adult stem cells and cancer stem cells, highlighting shared and distinct features, and reports no new clinical results.
19 citations
,
August 2023 in “Experimental & Molecular Medicine” This study found that the CXXC5 protein is overexpressed in diabetic foot ulcer tissues, suppressing wound healing, and that the small molecule KY19334 accelerated healing in diabetic mice by activating the Wnt/β-catenin pathway.
19 citations
,
November 2018 in “Experimental Dermatology” This review explores the skin regeneration process in spiny mice and highlights differences from laboratory mice, focusing on potential molecular and immune system roles without reporting new experimental results.