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In this study, aleglitazar and its metabolite M6 were evaluated for safety in non-clinical settings, revealing organ-targeting effects common to PPAR agonists but no significant tumor increase in rat carcinogenicity studies, supporting progression to Phase 3 clinical trials.

This study found that women with PCOS had significant hormonal imbalances, increased central obesity, and a lower 2D:4D digit ratio, suggesting prenatal androgen exposure may play a role in the condition's development.

This study identified three subgroups of women with PCOS with distinct androgen profiles, finding that the subgroup with adrenal-derived androgen excess had the highest insulin resistance and rates of hirsutism and hair loss.

This study found that young women with polycystic ovary syndrome had a higher risk of developing hypertension and metabolic syndrome compared to healthy controls, although these risks decreased after age 40.

Hair loss linked to higher heart disease risk in both men and women.

This study found that in women with polycystic ovary syndrome, xanthine oxidase activity is a useful marker for oxidative stress and is positively correlated with inflammatory markers and cardiovascular disease risk factors.

This study found that older women with polycystic ovarian syndrome are more likely to experience metabolic syndrome and have different metabolic and reproductive profiles than younger women.

This review discusses the impact of gender affirming hormone therapy on cardiovascular outcomes in transgender individuals and reports no new clinical results; the authors underscore the need for more comprehensive studies.

In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.

This study reported a similar prevalence of metabolic syndrome in patients with alopecia areata as in healthy controls, with no statistically significant differences observed.

This study found that patients with Alopecia Areata, particularly those with severe forms, exhibited higher triglycerides, cholesterol, and low-density lipoproteins, suggesting increased cardiovascular risk factors.

Early hair loss may signal metabolic issues but doesn't predict diabetes.

Early hair loss might indicate diabetes and heart risks, especially in those under 45.

This study found that in Korean patients, cardiovascular disease-related risk was significantly associated with male sex, moderate to severe androgenetic alopecia, and particularly FV-type alopecia.

This review highlights the increasing association of metabolic syndrome with various dermatological conditions and suggests a link through chronic inflammation, oxidative stress, and endocrine abnormalities, yet reports no new findings.

This study found that the total testosterone/dihydrotestosterone ratio is significantly higher in women with polycystic ovary syndrome and is associated with a worse metabolic profile in both PCOS and healthy women.

This study found that psoriasis patients had a significantly higher prevalence of autoimmune diseases and other comorbidities compared to those without psoriasis.

This systematic review observed that most studies found a higher prevalence of metabolic syndrome in women with female androgenetic alopecia, suggesting it may be a marker for metabolic abnormalities and cardiovascular risk, though some regional studies reported no significant association.

This review discusses the associations between dermatological disorders and increased cardiovascular risk, emphasizing that skin conditions with chronic inflammation may elevate the likelihood of cardiovascular diseases.

This study found that early-onset androgenetic alopecia is associated with higher prevalence of metabolic syndrome, atheroma plaques, and urinary symptoms related to prostate growth compared to controls.

This review provides an overview of the risks and side effects associated with common medications used to treat benign prostatic hyperplasia, highlighting the importance for clinicians and patients to discuss these aspects for informed decision-making.

In this study of Bulgarian women, the waist-to-stature ratio was a better marker for an unfavorable metabolic profile than the waist-to-hip ratio among those with PCOS and obesity.

In this study, male Koreans with androgenetic alopecia showed a significant association with hypertension, whereas females did not demonstrate this link.

This review discusses the possible link between prediabetes and hair loss, highlighting the need for further studies to evaluate this relationship and suggesting screenings for diabetes in patients with hair loss.

This review found that hyperandrogenism in premenopausal women is linked to a higher prevalence of cardiovascular risk factors and diseases regardless of obesity, while in postmenopausal women, these risks depend on obesity.

This review analyzes the potential mechanisms by which SARS-CoV-2 may exacerbate symptoms of benign prostatic hyperplasia and suggests a connection via ACE2 and androgen receptor pathways; it reports no new clinical results.

This study found that men with early-onset androgenetic alopecia had a higher prevalence of metabolic syndrome and carotid atheromatous plaques than control subjects, suggesting a need for cardiovascular screening in this group.

This study concluded that high-intensity interval training (HIIT) offers superior benefits over standard moderate-intensity continuous training (MICT) in improving aerobic capacity, insulin sensitivity, hormonal profiles, and anxiety scores in overweight women with PCOS.

This research review discusses the potential link between androgenetic alopecia and increased cardiovascular risk but does not report any new experimental findings.

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.