162 citations
,
January 2015 in “Trends in Endocrinology and Metabolism” This review discusses how women with PCOS have an increased risk of insulin resistance and cardiometabolic features regardless of body fat, and calls for targeted prevention and management strategies.
September 2025 in “Journal of Medical Sciences and Health” This study observed that among men aged 18 to 35 with early onset androgenetic alopecia, those with severe grades and metabolic syndrome may face increased cardiovascular risks, highlighting the importance of screening and monitoring.
May 2023 in “Journal of Cosmetic Dermatology” This study found that AGA patients had higher serum and epidermal irisin levels, which were associated with metabolic syndrome, dyslipidemia, and abnormal carotid intima media thickness, suggesting potential irisin resistance affecting cardiometabolic health.
13 citations
,
November 2015 in “Blood Pressure” This study found that early-onset androgenetic alopecia, especially with a vertex pattern, may be an independent risk factor for cardiovascular disease and metabolic syndrome in men.
5 citations
,
January 2018 in “Acta dermato-venereologica” This study identified an association between premature hair greying and larger waist circumference among young healthy subjects.
October 2023 in “Journal of the Endocrine Society” In this study, distinct androgen excess subtypes were identified in women with PCOS, with the adrenal androgen excess cluster showing significantly higher rates of insulin resistance and type 2 diabetes, suggesting 11-oxygenated androgens as potential drivers of metabolic risk.
July 2015 in “Egyptian Journal of Dermatology and Venereology” This study concluded that patients with androgenetic alopecia may have a higher risk of cardiovascular diseases compared to people without this condition.
16 citations
,
May 2013 in “Urology” The authors concluded that components of metabolic syndrome were strongly associated with severe lower urinary tract symptoms in Latin American men, while alopecia was not an independent predictor.
May 2024 in “Journal of cosmetic dermatology” This study found that early-onset male androgenetic alopecia is associated with abnormal lipid metabolism and lower levels of certain serum markers, which may serve as risk factors or protective factors for the condition.
April 2023 in “Nigerian Journal of Clinical Practice” In this study, androgenetic alopecia in Nigerians was associated with dyslipidemia, alcohol intake, and sedentary lifestyle, with severity linked to age, systolic blood pressure, and obesity.
This study found that women with postadolescent acne often exhibit symptoms of hyperandrogenism, such as hirsutism and androgenetic alopecia, but have minimal hormone profile abnormalities.
32 citations
,
April 2016 in “Journal of Obstetrics and Gynaecology Research” This study found that women with polycystic ovary syndrome phenotypes A and B had the highest prevalence of metabolic syndrome, and that the visceral adiposity index may help predict metabolic risk.
February 2009 in “Journal of The American Academy of Dermatology” People with early-onset hair loss have higher risk of heart issues, so early screening is important.
January 2008 in “Humana Press eBooks” This article reviews the relationship between polycystic ovary syndrome and various health issues but provides no new clinical findings; it emphasizes the need for continued research and lifestyle interventions.
4 citations
,
June 2019 in “International Journal of Dermatology and Venereology” This review discusses the link between metabolic syndrome and various inflammatory skin diseases and reports no new clinical results, emphasizing the importance of recognizing skin manifestations as early indicators of systemic metabolic disorders.
November 2025 in “Journal of Contemporary Medicine” This study observed that women with PCOS exhibited higher levels of triglycerides, fasting insulin, HOMA-IR, total testosterone, DHEAS, and LH/FSH ratio, and lower HDL cholesterol compared to healthy controls, with these markers varying across different PCOS phenotypes.
91 citations
,
December 2017 in “Systems Biology in Reproductive Medicine” This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.
February 2026 in “Diabetes Metabolic Syndrome and Obesity” This study identified a higher basal metabolic rate as an independent and causally relevant risk factor for nonalcoholic fatty liver disease in the Chinese population, noting that sex-specific effects may require tailored management strategies.
September 2022 in “Biomedicines” This study found that lipid accumulation product (LAP) and free androgen index (FAI) can highly predict liver steatosis in women with PCOS phenotype A.
December 2025 in “Çukurova medical journal (Online)/Çukurova medical journal” In this retrospective review, increased frequencies of certain HLA-DRB1 alleles and low vitamin D3 levels were observed in men with androgenetic alopecia, suggesting an association with immunogenetic factors and potential relevance for screening and treatment decisions.
14 citations
,
July 2016 in “Fertility and Sterility” This study found that increasing the follicle number criteria for diagnosing PCOS to 25 per ovary excluded some women who continue to show evidence of metabolic risk.
April 2026 in “Diagnostics” This study found that skin changes in morbidly obese individuals are associated with underlying metabolic disturbances but are not currently valuable as independent tools for assessing metabolic risk or treatment response.
3 citations
,
January 2022 in “Anais Brasileiros De Dermatologia” This study suggests that pediatric androgenetic alopecia is often associated with metabolic syndrome risk factors, highlighting the importance of early diagnosis for potential future health complications.
12 citations
,
October 2018 in “Journal of Mind and Medical Sciences” This study found that an unhealthy lifestyle, including factors like past smoking and lack of fruit/vegetables in the diet, was associated with an increased risk of metabolic syndrome.
January 2022 in “Surgical and Cosmetic Dermatology” This study found a significant correlation between androgenic alopecia and metabolic syndrome, suggesting individuals with alopecia have higher odds of metabolic syndrome.
5 citations
,
January 2017 in “Acta Endocrinologica” This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.
17 citations
,
May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews” This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.
8 citations
,
March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.
52 citations
,
February 2018 in “Diabetology & Metabolic Syndrome” This review discusses the association between various skin conditions and metabolic syndrome, reporting no new clinical results but suggesting a potential reciprocal relationship that warrants further investigation.
45 citations
,
February 2012 Among obese women potentially eligible for combined oral contraceptives, this study observed a higher frequency of non-alcoholic fatty liver disease in those with polycystic ovary syndrome.